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使用生物信息学方法检索和研究严重急性呼吸综合征冠状病毒2(SARS-CoV-2)及2019冠状病毒病(COVID-19)的数据

Retrieval and Investigation of Data on SARS-CoV-2 and COVID-19 Using Bioinformatics Approach.

作者信息

Fahmi Muhamad, Kharisma Viol Dhea, Ansori Arif Nur Muhammad, Ito Masahiro

机构信息

Advanced Life Sciences Program, Graduate School of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.

Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Kusatsu, Japan.

出版信息

Adv Exp Med Biol. 2021;1318:839-857. doi: 10.1007/978-3-030-63761-3_47.

Abstract

Sudden emergence and a rapid outbreak of SARS-CoV-2 accompanied by a devastating impact on the economy and public health has driven extensive scientific mobilization to study and elucidate the various associated concerns about SARS-CoV-2. Bioinformatics plays a crucial role in addressing and providing solutions to questions about SARS-CoV-2. It helps shorten the duration for the vaccine development process and the discovery of potential clinical interventions through the simulation and information retrieval, and the development of well-ordered information hubs and resources, which are essential to derive data and meaningful findings from the current massive information about SARS-CoV-2. Advanced algorithms in this field also provide approaches that are essential to elucidate the relationship, origin, and evolutionary process of SARS-CoV-2. Here, we report essential bioinformatics entities, such as database and platform development, molecular evolution and phylogenetic analyses, and vaccine designs, that are useful to solve the SARS-CoV-2 conundrum.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的突然出现和迅速爆发,对经济和公共卫生造成了毁灭性影响,促使科学界广泛动员起来,研究并阐明与SARS-CoV-2相关的各种问题。生物信息学在解决有关SARS-CoV-2的问题并提供解决方案方面发挥着关键作用。它有助于通过模拟和信息检索,以及开发有序的信息中心和资源,缩短疫苗研发过程的时间,并发现潜在的临床干预措施,而这些对于从当前关于SARS-CoV-2的海量信息中获取数据和有意义的发现至关重要。该领域的先进算法还提供了阐明SARS-CoV-2的关系、起源和进化过程所必需的方法。在此,我们报告了一些重要的生物信息学实体,如数据库和平台开发、分子进化和系统发育分析以及疫苗设计,这些对于解决SARS-CoV-2难题很有用。

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