Department of Urology, Van Training and Research Hospital, Edremit, Turkey.
Andrologia. 2021 Aug;53(7):e14073. doi: 10.1111/and.14073. Epub 2021 May 10.
Research has found that, instead of passive lipid-accumulated vascular damage, atherosclerosis which is the primary cause of erectile dysfunction (ED) can be seen as an active inflammatory cycle and that inflammation has a central role in the entire atherosclerotic process. As an inflammatory marker, serum C-reactive protein (CRP)/albumin ratio (CAR) may link to ED and ED severity. The CAR, demographic features and other criteria of 198 patients with ED who visited our outpatient clinic during March 2019-April 2020 were prospectively evaluated. The research also included healthy control subjects without systemic or infectious diseases. The mean difference of CAR between ED and no ED was statistically significant (0.55 ± 0.27 and 0.79 ± 0.49, p = .002 respectively). On the basis of the ROC analysis, CAR has a good ED diagnostic value with an area under the curve (AUC) of 0.63 (95% CI:0.541-0.714) and better diagnostic performance to distinguish ED severity (AUC:0.73, 95% CI:0.620-0.842). Additionally, mean CAR gradually increased with increasing severity of ED (for all p < .001). The CAR has been described as an independent ED indicator in the multivariate analysis (p = .001OR = 8.934; 95% CI:2.449-32.583). Increased CAR is associated with ED severity and increased ED risk. For CAR predicting ED and ED severity, a considerable cut-off point was identified.
研究发现，勃起功能障碍（ED）的主要病因——动脉粥样硬化，与其说是被动的脂质积累性血管损伤，不如说是一种主动的炎症循环，炎症在整个动脉粥样硬化过程中起着核心作用。作为一种炎症标志物，血清 C 反应蛋白（CRP）/白蛋白比值（CAR）可能与 ED 及其严重程度相关。本研究前瞻性评估了 2019 年 3 月至 2020 年 4 月期间在我院门诊就诊的 198 例 ED 患者的 CAR、人口统计学特征和其他标准，还纳入了无全身性或传染性疾病的健康对照受试者。ED 组和非 ED 组的 CAR 平均值差异具有统计学意义（分别为 0.55 ± 0.27 和 0.79 ± 0.49，p =.002）。基于 ROC 分析，CAR 对 ED 具有良好的诊断价值，曲线下面积（AUC）为 0.63（95% CI：0.541-0.714），并且对区分 ED 严重程度的诊断性能更好（AUC：0.73，95% CI：0.620-0.842）。此外，随着 ED 严重程度的增加，平均 CAR 逐渐升高（所有 p <.001）。多元分析显示，CAR 是 ED 的独立指标（p =.001OR = 8.934；95% CI：2.449-32.583）。CAR 的增加与 ED 的严重程度和 ED 风险的增加相关。对于 CAR 预测 ED 和 ED 严重程度，确定了一个相当的截断值。
