Arslan Burak, Kecebas Arif Burak, Ates Alaaddin, Gurkan Okan, Cetin Bugra, Kardas Sina, Ekinci Suat, Ozalevli Mehmet, Aydin Muammer, Özdemir Enver
Department of Urology, University of Health Sciences Gaziosmanpaşa Training and Research Hospital, Istanbul, Turkey.
Department of Radiology, University of Health Sciences Gaziosmanpaşa Training and Research Hospital, Istanbul, Turkey.
Int Urol Nephrol. 2023 Nov;55(11):2773-2779. doi: 10.1007/s11255-023-03716-9. Epub 2023 Jul 24.
Our aim was to investigate the association of prognostic nutritional index (PNI) score with erectile dysfunction (ED), therefore, we prospectively evaluated the relationship between penile doppler ultrasonography (PDU) findings, PNI and Sexual Health Inventory for Men (SHIM) scores in patients with ED.
A total of 414 patients' characteristics, laboratory findings, SHIM and PNI scores were recorded. The PNI is calculated using the formula: 10 × serum albumin + 0.005 × total lymphocyte count. PDU was performed in patients with a SHIM score of 17 and below, while patients with a SHIM score ≥ 18 were recruited for the control group. Correlation analysis was performed to evaluate the relationship between PNI, SHIM scores and PDU parameters. The predictive value of variables for severe ED was assessed with regression analysis.
A significant difference was demonstrated between the ED subgroups and control group for total cholesterol (p = 0.04), serum albumin (p = 0.03), total lymphocyte count (p = 0.02), BDI score (p < 0.001), and PNI score (p = 0.03). A strong positive correlation between PNI score and PSV (rho = 0.73; p = 0.001), a moderate negative correlation between PNI score and EDV (rho = - 0.54; p = 0.02), and a moderate positive correlation between PNI and SHIM scores (rho = 0.61; p = 0.02) were demonstrated. PNI score ≤ 40 (OR: 3.49; p = 0.01), age (OR: 2.15; p = 0.03) and total cholesterol (OR: 2.03; p = 0.04) were determined as significant predictors of severe ED in multivariate analysis.
Our results demonstrated that PNI score is significantly lower in patients with severe and moderate ED. It has been also revealed that the PNI score is an independent predictive factor for severe ED.
我们的目的是研究预后营养指数（PNI）评分与勃起功能障碍（ED）之间的关联，因此，我们前瞻性地评估了ED患者阴茎多普勒超声检查（PDU）结果、PNI与男性性健康量表（SHIM）评分之间的关系。
记录了414例患者的特征、实验室检查结果、SHIM和PNI评分。PNI使用公式计算：10×血清白蛋白+0.005×总淋巴细胞计数。对SHIM评分为17及以下的患者进行PDU检查，而SHIM评分≥18的患者被纳入对照组。进行相关性分析以评估PNI、SHIM评分与PDU参数之间的关系。通过回归分析评估变量对重度ED的预测价值。
ED亚组与对照组在总胆固醇（p = 0.04）、血清白蛋白（p = 0.03）、总淋巴细胞计数（p = 0.02）、BDI评分（p < 0.001）和PNI评分（p = 0.03）方面存在显著差异。PNI评分与PSV之间存在强正相关（rho = 0.73；p = 0.001），PNI评分与EDV之间存在中度负相关（rho = -0.54；p = 0.02），PNI与SHIM评分之间存在中度正相关（rho = 0.61；p = 0.02）。在多变量分析中，PNI评分≤40（OR：3.49；p = 0.01）、年龄（OR：2.15；p = 0.03）和总胆固醇（OR：2.03；p = 0.04）被确定为重度ED的显著预测因素。
我们的结果表明，重度和中度ED患者的PNI评分显著更低。还发现PNI评分是重度ED的独立预测因素。
