The Shmunis School of Biomedicine and Cancer Research Faculty of Life Sciences Tel Aviv University Tel Aviv 6997801 Israel.
Department of Materials Science and Engineering Faculty of Engineering Tel Aviv University Tel Aviv 6997801 Israel.
Adv Sci (Weinh). 2021 Mar 2;8(9):2004205. doi: 10.1002/advs.202004205. eCollection 2021 May.
Three dimensional (3D) printing of heart patches usually provides the ability to precisely control cell location in 3D space. Here, one-step 3D printing of cardiac patches with built-in soft and stretchable electronics is reported. The tissue is simultaneously printed using three distinct bioinks for the cells, for the conducting parts of the electronics and for the dielectric components. It is shown that the hybrid system can withstand continuous physical deformations as those taking place in the contracting myocardium. The electronic patch is flexible, stretchable, and soft, and the electrodes within the printed patch are able to monitor the function of the engineered tissue by providing extracellular potentials. Furthermore, the system allowed controlling tissue function by providing electrical stimulation for pacing. It is envisioned that such transplantable patches may regain heart contractility and allow the physician to monitor the implant function as well as to efficiently intervene from afar when needed.
三维（3D）打印心脏贴片通常能够精确控制细胞在 3D 空间中的位置。在这里，报道了一种一步法 3D 打印具有内置柔软和可拉伸电子器件的心脏贴片。组织同时使用三种不同的生物墨水进行打印，一种用于细胞，一种用于电子器件的导电部分，一种用于介电组件。结果表明，混合系统能够承受类似于心肌收缩时发生的连续物理变形。电子贴片具有柔韧性、可拉伸性和柔软性，并且打印贴片内的电极能够通过提供细胞外电势来监测工程组织的功能。此外，该系统通过提供起搏电刺激来控制组织功能。可以设想，这种可移植的贴片可以恢复心脏的收缩性，并允许医生监测植入物的功能，以及在需要时从远处进行有效的干预。
