Sun Lingyu, Wang Yu, Xu Dongyu, Zhao Yuanjin
Department of Rheumatology and Immunology Institute of Translational Medicine Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing China.
Smart Med. 2023 Feb 16;2(1):e20220040. doi: 10.1002/SMMD.20220040. eCollection 2023 Feb.
Heart diseases, especially cardiovascular diseases, have brought heavy burden on society for their high morbidity and mortality. In clinical, heart transplantation is recognized as an effective strategy to rescue the lives of patients, while it may suffer from lack of donors and possible immune responses. In view of this, tremendous efforts have been devoted to developing alternative strategies to recover the function and promote the regeneration of cardiac tissues. As an emerging field blending cell biology and material science, tissue engineering technique allows the construction of biomimetic living complexes as organ substitutes for heart repair. In this review, we will present the recent progress in cardiac tissue engineering and artificial hearts. After introducing the critical elements in cardiac tissue engineering, we will present advanced fabrication methods to achieve scaffolds with desired micro/nanostructure design as well as the applications of these bioinspired scaffolds. We will also discuss the current dilemma and possible development direction from a biomedical perspective.
心脏病，尤其是心血管疾病，因其高发病率和高死亡率给社会带来了沉重负担。在临床上，心脏移植被认为是挽救患者生命的有效策略，但其可能面临供体短缺和潜在免疫反应的问题。鉴于此，人们已投入巨大努力来开发替代策略，以恢复心脏组织功能并促进其再生。作为一个融合细胞生物学和材料科学的新兴领域，组织工程技术能够构建仿生活性复合物作为心脏修复的器官替代物。在本综述中，我们将介绍心脏组织工程和人工心脏的最新进展。在介绍心脏组织工程的关键要素后，我们将展示实现具有所需微/纳米结构设计的支架的先进制造方法以及这些仿生支架的应用。我们还将从生物医学角度讨论当前的困境和可能的发展方向。
