Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Hokkaido, Japan.
Infectious Cancer, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Hokkaido, Japan.
Int Immunol. 2022 Jan 22;34(2):59-65. doi: 10.1093/intimm/dxab022.
Gateway reflexes are neural circuits that maintain homeostasis of the immune system. They form gateways for autoreactive T cells to infiltrate the central nervous system in a noradrenaline-dependent manner despite the blood-brain barrier. This mechanism is critical not only for maintaining organ homeostasis but also for inflammatory disease development. Gateway reflexes can be regulated by environmental or artificial stimuli including electrical stimulation, suggesting that the infiltration of immune cells can be controlled by bioelectronic medicine. In this review, we describe the discovery of gateway reflexes and their future directions with special focus on bioelectronic medicine.
门控反射是维持免疫系统内稳态的神经回路。它们形成了门控，使自身反应性 T 细胞能够在去甲肾上腺素依赖的情况下穿透血脑屏障进入中枢神经系统。这种机制不仅对于维持器官内稳态至关重要，而且对于炎症性疾病的发展也至关重要。门控反射可以通过环境或人工刺激（包括电刺激）来调节，这表明免疫细胞的浸润可以通过生物电子医学来控制。在这篇综述中，我们描述了门控反射的发现及其未来方向，特别关注生物电子医学。
