Department of Medical Ecology and Hydroclimatology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Department of Medical Ecology and Hydroclimatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Clin Rheumatol. 2022 Jan;41(1):289-296. doi: 10.1007/s10067-021-05942-x. Epub 2021 Oct 29.
To document the detailed characteristics including severity, type, and locations of rheumatic and musculoskeletal symptoms along with other COVID-19 persistent symptoms in hospitalized COVID-19 survivors at 3 and 6 months.
In this extension cohort study, two telephone surveys at 3 and 6 months following the hospitalization were carried out. In these telephone surveys, participants were asked regarding their symptoms through a previously designed standard questionnaire.
At 3 months, 89.0% of survivors had at least one symptom, 74.6% had at least one rheumatic and musculoskeletal symptom, and 82.1% had at least one other COVID-19 symptom. At 6 months, 59.6% of survivors had at least one symptom, 43.2% had at least one rheumatic and musculoskeletal symptom, and 51.2% had at least one other COVID-19 symptom. Regarding the rheumatic and musculoskeletal symptoms, 31.6% had fatigue, 18.6% had joint pain, and 15.1% had myalgia; and regarding the other-COVID-19-symptoms, 25.3% had dyspnea, 20.0% had hair loss, and 17.2% sweat at 6 months. In an adjusted model, female patients were more likely to have fatigue (OR: 1.99, 95% CI: 1.18-3.34), myalgia (3.00, 1.51-5.98), and joint pain (3.39, 1.78-6.50) at 6 months.
Approximately 3 in 5 patients had at least one symptom with ≈2 in 5 patients had at least one rheumatic and musculoskeletal symptom. Fatigue, joint pain, and myalgia were the most frequent rheumatic and musculoskeletal symptoms. Joint pain and myalgia were mostly widespread. This information guide rheumatologists to understand the nature and features of persistent rheumatic and musculoskeletal symptoms in hospitalized COVID-19 survivors and may contribute to better management of these individuals. Key Points • Approximately 3 in 5 patients had at least one symptom with ≈2 in 5 patients had at least one rheumatic and musculoskeletal symptom at 6 months • Fatigue, joint pain, and myalgia were the most frequent rheumatic and musculoskeletal symptoms followed by back pain, low back pain, and neck pain • Dyspnea, hair loss, and sweat were the most frequent other-COVID-19-symptoms.
记录 COVID-19 住院幸存者在 3 个月和 6 个月时风湿和肌肉骨骼症状的严重程度、类型和部位等详细特征以及其他 COVID-19 持续症状。
在这项扩展队列研究中，在住院后进行了 3 个月和 6 个月的两次电话调查。在这些电话调查中，通过之前设计的标准问卷询问参与者他们的症状。
在 3 个月时，89.0%的幸存者至少有一种症状，74.6%的幸存者至少有一种风湿和肌肉骨骼症状，82.1%的幸存者至少有一种其他 COVID-19 症状。在 6 个月时，59.6%的幸存者至少有一种症状，43.2%的幸存者至少有一种风湿和肌肉骨骼症状，51.2%的幸存者至少有一种其他 COVID-19 症状。在风湿和肌肉骨骼症状方面，31.6%的患者有疲劳，18.6%的患者有关节疼痛，15.1%的患者有肌肉疼痛；在其他 COVID-19 症状方面，25.3%的患者有呼吸困难，20.0%的患者有脱发，17.2%的患者在 6 个月时出汗。在调整后的模型中，女性患者更有可能在 6 个月时出现疲劳（比值比：1.99，95%可信区间：1.18-3.34）、肌肉疼痛（3.00，1.51-5.98）和关节疼痛（3.39，1.78-6.50）。
大约每 5 个患者中就有 3 个至少有一种症状，大约每 5 个患者中就有 2 个至少有一种风湿和肌肉骨骼症状。疲劳、关节疼痛和肌肉疼痛是最常见的风湿和肌肉骨骼症状。关节疼痛和肌肉疼痛多为广泛性的。这些信息指导风湿病医生了解住院 COVID-19 幸存者持续存在的风湿和肌肉骨骼症状的性质和特征，并有助于更好地管理这些患者。关键点：
· 大约每 5 个患者中就有 3 个至少有一种症状，大约每 5 个患者中就有 2 个至少有一种风湿和肌肉骨骼症状，在 6 个月时；
· 疲劳、关节疼痛和肌肉疼痛是最常见的风湿和肌肉骨骼症状，其次是背痛、下腰痛和颈痛；
· 呼吸困难、脱发和出汗是最常见的其他 COVID-19 症状。
