Department of Psychology, University of New Mexico, Albuquerque, NM, 87109, Mexico.
Department of Psychology, University of New Mexico, Albuquerque, NM, 87109, Mexico.
Neurosci Biobehav Rev. 2021 Aug;127:647-658. doi: 10.1016/j.neubiorev.2021.05.005. Epub 2021 May 9.
Alzheimer's disease (AD) pathology is commonly associated with cognitive decline but is also composed of neuropsychiatric symptoms including psychological distress and alterations in mood, including anxiety and depression. Emotional dysfunction in AD is frequently modeled using tests of anxiety-like behavior in transgenic rodents. These tests often include the elevated plus-maze, light/dark test and open field test. In this review, we describe prototypical behavioral paradigms used to examine emotional dysfunction in transgenic models of AD, specifically anxiety-like behavior. Next, we summarize the results of studies examining anxiety-like behavior in transgenic rodents, noting that the behavioral outcomes using these paradigms have produced inconsistent results. We suggest that future research will benefit from using a battery of tests to examine emotional behavior in transgenic AD models. We conclude by discussing putative, overlapping neurobiological mechanisms underlying AD-related neuropathology, stress and anxiety-like behavior reported in AD models.
阿尔茨海默病（AD）的病理变化通常与认知能力下降有关，但也包括神经精神症状，包括心理困扰和情绪变化，包括焦虑和抑郁。AD 的情绪功能障碍通常使用转基因啮齿动物的焦虑样行为测试来建模。这些测试通常包括高架十字迷宫、明暗试验和旷场试验。在这篇综述中，我们描述了用于检查 AD 转基因模型中情绪功能障碍的典型行为范式，特别是焦虑样行为。接下来，我们总结了检查转基因啮齿动物焦虑样行为的研究结果，指出使用这些范式的行为结果产生了不一致的结果。我们建议，未来的研究将受益于使用一系列测试来检查转基因 AD 模型中的情绪行为。最后，我们讨论了 AD 相关神经病理学、AD 模型中报告的应激和焦虑样行为背后假定的重叠神经生物学机制。
