Cauli A, Montaldo C, Peltz M T, Nurchis P, Sanna G, Garau P, Pala R, Passiu G, Mathieu A
Department of Clinical Medicine, University of Cagliari, Italy.
Clin Rheumatol. 1994 Dec;13(4):615-8. doi: 10.1007/BF02243004.
Forty randomly selected patients with systemic lupus erythematosus (SLE) were studied by clinical and serologic parameters and magnetic resonance imaging (MRI). Abnormal MRI was found in 15/40 patients (37.5%): all 15 cases showed multiple widespread small-sized areas of increased signal in T2 in the white matter; in one of these patients MRI also displayed a large area with a reduced signal in T1 and an increased signal in T2 involving both the white and the gray matter. Among the 15 patients with abnormal MRI, only 7 had neuropsychiatric symptoms. The presence of MRI changes was highest in patients with organic type symptoms and was associated to the highest disease severity scores. A long-term follow up of asymptomatic patients would be useful to establish whether the application of MRI is appropriate for the assessment of CNS involvement in SLE.
通过临床、血清学参数及磁共振成像（MRI）对40例随机选取的系统性红斑狼疮（SLE）患者进行了研究。40例患者中有15例（37.5%）MRI异常：15例均显示白质T2加权像上有多个广泛分布的小面积信号增强区；其中1例患者MRI还显示T1加权像上有一大片信号减低区，T2加权像上信号增强，累及白质和灰质。在15例MRI异常的患者中，只有7例有神经精神症状。MRI改变在有器质性症状的患者中最为常见，且与最高疾病严重程度评分相关。对无症状患者进行长期随访，有助于确定MRI是否适用于评估SLE患者的中枢神经系统受累情况。
