Ucok Alp, Karakaş Begüm, Şahin Olcay Şenay
Department of Psychiatry, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Department of Psychiatry, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Psychiatry Res. 2021 Jul;301:113972. doi: 10.1016/j.psychres.2021.113972. Epub 2021 Apr 29.
Formal thought disorder (FTD) refers to abnormal speech patterns that can be characterized by deficiencies in thought organization and direction. The present study aimed to assess the factor structure of FTD and to examine its relationship with cognition and clinical features at first admission in patients with first-episode schizophrenia. We also examined the course of FTD during the twelve months after first admission. We assessed FTD using the alogia items of the Scale for the Assessment of Negative Symptoms and FTD items of the Scale for the Assessment of Positive Symptoms in 160 drug-naïve patients. A three-factor structure as a disorganization factor, poverty factor, and verbosity factor were found in principal component analysis. The poverty factor was correlated negatively with executive functions, attention, and global cognition. The poverty factor was also correlated with global functioning. Admission FTD factor scores were not related to global functioning and work/study status at one year. The positive-FTD score decreased from admission to the third month, but no change occurred from the third to the twelfth month. The negative-FTD score did not differ throughout the follow-up. Our findings showed that FTD had three factors. Each factor had a different relationship with cognition and functioning.
形式思维障碍（FTD）是指异常的言语模式，其特征可能是思维组织和方向存在缺陷。本研究旨在评估FTD的因素结构，并探讨其与首发精神分裂症患者首次入院时的认知及临床特征之间的关系。我们还研究了首次入院后十二个月内FTD的病程。我们使用阴性症状评估量表中的言语贫乏项目和阳性症状评估量表中的FTD项目，对160例未使用过药物的患者进行了FTD评估。在主成分分析中发现了一个由紊乱因素、贫乏因素和多言因素组成的三因素结构。贫乏因素与执行功能、注意力和整体认知呈负相关。贫乏因素也与整体功能有关。入院时的FTD因素得分与一年后的整体功能及工作/学习状态无关。阳性FTD得分从入院到第三个月下降，但从第三个月到第十二个月没有变化。阴性FTD得分在整个随访过程中没有差异。我们的研究结果表明，FTD有三个因素。每个因素与认知和功能的关系不同。
