Shuff Sydney, Oyama Yoshimasa, Walker Lori, Eckle Tobias
Department of Anesthesiology, University of Colorado Denver School of Medicine, Aurora, CO, USA.
Department of Anesthesiology, University of Colorado Denver School of Medicine, Aurora, CO, USA; Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Oita, Japan.
Trends Mol Med. 2021 Jul;27(7):627-629. doi: 10.1016/j.molmed.2021.04.007. Epub 2021 May 10.
Angiopoietin-like 4 (ANGPTL4) is critical for regulating plasma lipids, and thus an attractive therapeutic target for cardiovascular diseases. Unfortunately, targeting ANGPTL4 results in a proinflammatory and ultimately lethal phenotype in animals. The serendipitous discovery of cardiac ANGPTL4 as a circadian protein reveals novel mechanistic insight and a solution for this therapeutic dilemma.
血管生成素样蛋白4（ANGPTL4）对调节血脂至关重要，因此是心血管疾病颇具吸引力的治疗靶点。遗憾的是，针对ANGPTL4会在动物体内导致促炎并最终致命的表型。意外发现心脏中的ANGPTL4是一种昼夜节律蛋白，揭示了新的机制见解以及解决这一治疗困境的办法。
