Facultad de Ciencias de la Salud, Escuela de Medicina Humana, Universidad Científica del Sur, Lima, Perú.
Department of Cardiology Research, Torres de Salud National Research Center, Lima, Peru.
Eur J Neurol. 2021 Oct;28(10):3467-3477. doi: 10.1111/ene.14912. Epub 2021 Jun 9.
There is debate as to whether there is an increased risk of COVID-19 infection in people with Parkinson's disease (PD), possibly due to associated factors. This study aimed to systematically review the factors associated with COVID-19 in people with PD.
A search was carried out in PubMed, Scopus, and Web of Science up to November 2020 (updated until 1 April 2021). Observational studies that analyzed factors associated with COVID-19 in people with PD were selected and revised.
The authors included six studies (four case-controlled studies and two cross-sectional studies) in the qualitative and quantitative syntheses. The authors found that the following factors were associated with COVID-19 in people with PD: obesity (OR: 1.79, 95% CI: 1.07-2.99, I : 0%), any pulmonary disease (OR: 1.92, 95% CI: 1.17-3.15, I : 0%), COVID-19 contact (OR: 41.77, 95% CI: 4.77 - 365.56, I : 0%), vitamin D supplementation (OR: 0.50, 95% CI: 0.30-0.83, I : 0%), hospitalization (OR: 11.78, 95% CI: 6.27-22.12, I : 0%), and death (OR: 11.23, 95% CI: 3.92-32.18, I : 0%). The authors did not find any significant association between COVID-19 and hypertension, diabetes, cardiopathy, cancer, any cognitive problem, dementia, chronic obstructive pulmonary disease, renal or hepatic disease, smoking, and tremor.
Meta-analyses were limited by the number of events and some methodological limitations. Despite this, the authors assessed the available evidence, and the results may be useful for future health policies.
由于与帕金森病（PD）相关的因素，人们对于 PD 患者感染 COVID-19 的风险是否增加存在争议。本研究旨在系统地回顾与 PD 患者 COVID-19 相关的因素。
作者在 PubMed、Scopus 和 Web of Science 上进行了检索，检索时间截至 2020 年 11 月（更新至 2021 年 4 月 1 日）。选择并修订了分析 PD 患者 COVID-19 相关因素的观察性研究。
作者纳入了定性和定量综合分析的六项研究（四项病例对照研究和两项横断面研究）。作者发现，以下因素与 PD 患者的 COVID-19 相关：肥胖（OR：1.79，95%CI：1.07-2.99，I²：0%）、任何肺部疾病（OR：1.92，95%CI：1.17-3.15，I²：0%）、COVID-19 接触史（OR：41.77，95%CI：4.77-365.56，I²：0%）、维生素 D 补充（OR：0.50，95%CI：0.30-0.83，I²：0%）、住院治疗（OR：11.78，95%CI：6.27-22.12，I²：0%）和死亡（OR：11.23，95%CI：3.92-32.18，I²：0%）。作者未发现 COVID-19 与高血压、糖尿病、心脏病、癌症、任何认知问题、痴呆、慢性阻塞性肺疾病、肾病或肝病、吸烟和震颤之间存在显著相关性。
由于事件数量和一些方法学上的限制，荟萃分析受到限制。尽管如此，作者还是评估了现有证据，结果可能对未来的卫生政策有用。
