Oh Tak Kyu, Song In-Ae
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
J Crit Care. 2021 Aug;64:193-198. doi: 10.1016/j.jcrc.2021.04.018. Epub 2021 May 3.
This study aimed to investigate the incidence and effect of quality of life (QOL) change in Korean sepsis survivors.
Using the National Health Insurance claim database of South Korea, we included adult sepsis survivors who were primarily diagnosed with sepsis between 2010 and 2018 and survived for more than 1 year after diagnosis. QOL change was defined using three criteria: decrease in annual income level, newly acquired disability, and increase in underlying comorbidities after sepsis.
A total of 119,660 sepsis survivors were included in the final analysis. Overall, worsening QOL was observed in 92,096 (77.0%) of the survivors. Specifically, compared with that of before sepsis diagnosis, 9778 sepsis survivors (8.2%) had a decrease in annual income level, and 10,648 (8.9%) were newly registered as having a disability. Additionally, 74,528 (62.3%) and 79,142 (66.1%) sepsis survivors showed an increase in the Charlson and Elixhauser comorbidity indices, respectively. Among sepsis survivors, post-sepsis disability and increase in comorbidity indices were associated with a higher risk of 3-year all-cause mortality.
We found that most sepsis survivors experienced a worsening in their QOL, which was associated with a higher risk of long-term mortality.
本研究旨在调查韩国脓毒症幸存者生活质量（QOL）变化的发生率及其影响。
利用韩国国民健康保险索赔数据库，我们纳入了2010年至2018年间首次被诊断为脓毒症且诊断后存活超过1年的成年脓毒症幸存者。生活质量变化采用三个标准来定义：年收入水平下降、新获得残疾以及脓毒症后基础合并症增加。
最终分析共纳入119,660名脓毒症幸存者。总体而言，92,096名（77.0%）幸存者的生活质量出现恶化。具体而言，与脓毒症诊断前相比，9778名（8.2%）脓毒症幸存者年收入水平下降，10,648名（8.9%）新登记为残疾。此外，分别有74,528名（62.3%）和79,142名（66.1%）脓毒症幸存者的查尔森合并症指数和埃利克斯豪泽合并症指数增加。在脓毒症幸存者中，脓毒症后残疾和合并症指数增加与3年全因死亡率较高风险相关。
我们发现大多数脓毒症幸存者的生活质量恶化，这与长期死亡率较高风险相关。
