Song In-Ae, Park Hye Yoon, Oh Tak Kyu
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Department of Psychiatry, Seoul National University Hospital, Seoul, South Korea.
Nat Sci Sleep. 2021 Jun 29;13:979-988. doi: 10.2147/NSS.S319769. eCollection 2021.
We aimed to investigate the association of sleep disorder diagnosis among sepsis survivors with 5-year all-cause mortality.
Using the National Health Insurance Service (NHIS) database of South Korea, we included adult sepsis survivors who were primarily diagnosed with sepsis between 2011 and 2014 and survived for more than one year after diagnosis. The diagnosis of sleep disorders was evaluated using the International Classification of Diseases, 10th revision codes of G47* in the NHIS database.
In total, 45,826 survivors of sepsis were included in this analysis. Among the sepsis survivors, 2935 (6.4%) were newly diagnosed with a sleep disorder within 1 year after the date of sepsis diagnosis, while 7938 (17.3%) were already diagnosed with sleep disorder before the date of sepsis diagnosis. In the multivariable Cox regression, the risk of 5-year all-cause mortality in the pre- and post-sepsis sleep disorder groups was 1.19-fold (hazard ratio: 1.19, 95% confidence interval: 1.14-1.24; <0.001) and 1.79-fold (hazard ratio: 1.79, 95% confidence interval: 1.70-1.89; <0.001) higher than that of the control group.
A 6.4% of sepsis survivors in South Korea were newly diagnosed with a sleep disorder within 1 year of sepsis diagnosis. Although both pre- and post-sepsis sleep disorders were associated with a higher 5-year all-cause mortality rate, the risk of the 5-year all-cause mortality in the post-sepsis sleep disorder group was higher than that in the pre-sepsis sleep disorder group.
我们旨在研究脓毒症幸存者睡眠障碍诊断与5年全因死亡率之间的关联。
利用韩国国民健康保险服务（NHIS）数据库，我们纳入了2011年至2014年间初次诊断为脓毒症且诊断后存活超过一年的成年脓毒症幸存者。使用NHIS数据库中《国际疾病分类》第10版G47*编码评估睡眠障碍诊断情况。
本分析共纳入45826名脓毒症幸存者。在脓毒症幸存者中，2935人（6.4%）在脓毒症诊断日期后1年内新诊断为睡眠障碍，而7938人（17.3%）在脓毒症诊断日期前已被诊断为睡眠障碍。在多变量Cox回归分析中，脓毒症前、后睡眠障碍组的5年全因死亡率风险分别比对照组高1.19倍（风险比：1.19，95%置信区间：1.14 - 1.24；P<0.001）和1.79倍（风险比：1.79，95%置信区间：1.70 - 1.89；P<0.001）。
韩国6.4%的脓毒症幸存者在脓毒症诊断后1年内新诊断为睡眠障碍。虽然脓毒症前、后的睡眠障碍均与较高的5年全因死亡率相关，但脓毒症后睡眠障碍组的5年全因死亡率风险高于脓毒症前睡眠障碍组。
