Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, 410078, China; Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, 410078, China.
Department of Inorganic Materials, School of Minerals Processing and Bioengineering, Central South University, Changsha, 410083, China.
Colloids Surf B Biointerfaces. 2021 Aug;204:111825. doi: 10.1016/j.colsurfb.2021.111825. Epub 2021 May 12.
The bone-tendon interface (BTI) is a graded structure consisting of bone, mineralized and nonmineralized fibrocartilage, and tendons. Due to the complexity of the BTI structure, BTI healing is particularly challenging. To achieve a better material for BTI healing, polycaprolactone (PCL)/hydroxyapatite (HA)/ZnO films were constructed by the electrospinning method; in addition, the relevant material characteristics were tested. After culturing MC3T-E1 cells, ATDC5 cells, mouse primary fibrochondrocytes, and mouse primary tenocytes on films, PCL-5%HA-1%ZnO films (HA and ZnO weight ratios of 5% and 1%, respectively) displayed superior cell compatibility and cell adhesion. PCL-5%HA-1%ZnO films also promoted osteogenesis, chondrogenesis, fibrocartilage formation, and tendon healing. The antibacterial characteristics of PCL-5%HA-1%ZnO films were also identified in this study. The PCL-5%HA-1%ZnO films have great application potential in the field of BTI repair.
骨-腱界面（BTI）是一种分级结构，由骨、矿化和非矿化纤维软骨以及肌腱组成。由于 BTI 结构的复杂性，BTI 愈合尤其具有挑战性。为了获得更好的 BTI 愈合材料，采用静电纺丝法构建了聚己内酯（PCL）/羟基磷灰石（HA）/氧化锌（ZnO）薄膜，并对相关材料特性进行了测试。将 MC3T-E1 细胞、ATDC5 细胞、小鼠原代纤维软骨细胞和小鼠原代肌腱细胞在薄膜上培养后，PCL-5%HA-1%ZnO 薄膜（HA 和 ZnO 的重量比分别为 5%和 1%）显示出优异的细胞相容性和细胞黏附性。PCL-5%HA-1%ZnO 薄膜还促进了成骨、软骨形成、纤维软骨形成和肌腱愈合。本研究还确定了 PCL-5%HA-1%ZnO 薄膜的抗菌特性。PCL-5%HA-1%ZnO 薄膜在 BTI 修复领域具有巨大的应用潜力。
