Zhu Senbo, He Zeju, Ji Lichen, Zhang Wei, Tong Yu, Luo Junchao, Zhang Yin, Li Yong, Meng Xiang, Bi Qing
Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Front Bioeng Biotechnol. 2022 Jun 30;10:897010. doi: 10.3389/fbioe.2022.897010. eCollection 2022.
The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21-60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people's quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration.
跟腱负责跑步、跳跃和站立。跟腱损伤在人群中非常常见。在成年人群（21至60岁）中，跟腱损伤的发生率约为每1000人中有2.35例。它对人们的生活质量产生负面影响，并增加医疗负担。由于跟腱细胞数量少且血管缺乏，其愈合能力较差。因此，跟腱损伤愈合引起了研究人员的广泛关注。目前的跟腱损伤治疗方法无法有效恢复跟腱的机械结构和功能，这推动了跟腱再生组织工程的发展。由于各种基于纳米纤维的支架与天然肌腱结构相似且具有促进组织再生的能力，目前正在对其进行探索。本文综述了当前跟腱再生的方法、基于纳米纤维的支架制造和增强方面的最新进展，以及用于跟腱再生的多尺度纳米纤维支架的开发和应用。
