超高场强与超高分辨率功能磁共振成像
ULTRAHIGH FIELD and ULTRAHIGH RESOLUTION fMRI.
作者信息
Uğurbil Kamil
机构信息
Center for Magnetic Resonance Research (CMRR), University of Minnesota, 2021 6 Street SE, Minneapolis, MN 55456.
出版信息
Curr Opin Biomed Eng. 2021 Jun;18. doi: 10.1016/j.cobme.2021.100288. Epub 2021 Apr 14.
Abstract
Functional magnetic resonance imaging (fMRI) has become one of the most powerful tools for investigating the human brain. Ultrahigh magnetic field (UHF) of 7 Tesla has played a critical role in enabling higher resolution and more accurate (relative to the neuronal activity) functional maps. However, even with these gains, the fMRI approach is challenged relative to the spatial scale over which brain function is organized. Therefore, going forward, significant advances in fMRI are still needed. Such advances will predominantly come from magnetic fields significantly higher than 7 Tesla, which is the most commonly used UHF platform today, and additional technologies that will include developments in pulse sequences, image reconstruction, noise suppression, and image analysis in order to further enhance and augment the gains than can be realized by going to higher magnetic fields.
摘要
功能磁共振成像（fMRI）已成为研究人类大脑最强大的工具之一。7特斯拉的超高磁场（UHF）在实现更高分辨率和更准确（相对于神经元活动）的功能图谱方面发挥了关键作用。然而，即便有这些进展，相对于大脑功能组织的空间尺度而言，fMRI方法仍面临挑战。因此，未来仍需要fMRI取得重大进展。这些进展将主要来自显著高于7特斯拉的磁场（7特斯拉是当今最常用的UHF平台），以及其他技术，这些技术将包括脉冲序列、图像重建、噪声抑制和图像分析等方面的发展，以便进一步增强和扩大通过提高磁场强度所能实现的成果。
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