Ck Anulekha Avinash, Tholupunuri Harshini, Reddy M Ramu, Muralidhar Mamatha, Jayyarapu Dilip, Nair Sangeeta
Kamineni Institute of Dental Sciences, Narketpally, Telangana, India.
Department of Prosthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India.
Glob Med Genet. 2021 Jun;8(2):51-56. doi: 10.1055/s-0041-1725069. Epub 2021 Mar 10.
Genes control approximately 60% to 75% of the variance of peak bone mass/density and a much smaller amount of variance in rate of loss. Bone mass increases during growth to a peak value and soon after begins to decline. Most of the genetic effect is exerted during growth and so influences peak bone mass; whether there is an additional genetic effect on the rate of bone loss is less clear. So, this article aims to place emphasis on various oral and systemic conditions that are manifested due to altered gene function. Genetic polymorphisms and mutations are simple, although the consequences of the mechanism are complex. The syndromic manifestation due to changes at genetic level will greatly affect the bone quality, which will ultimately affect any treatment prognosis. Hence, a better understanding of molecular mechanisms of bone remodeling helps to identify pathogenic causes of bone, skeletal diseases, and leads to the development of targeted therapies for these diseases. This review highlights notions on the connecting link between science and genetics as well as various oral scenarios where gene could bring about changes, resulting in deformities. There is an intense research awaited in the future which could intervene with the causes that bring about genetic modulations, so as to decrease the mortality rate of humans.
基因控制着约60%至75%的峰值骨量/骨密度差异，而对骨量流失速率的差异影响则小得多。骨量在生长过程中增加至峰值，之后不久便开始下降。大多数遗传效应在生长过程中发挥作用，因此影响峰值骨量；对于骨量流失速率是否存在额外的遗传效应尚不太明确。所以，本文旨在强调因基因功能改变而出现的各种口腔及全身状况。基因多态性和突变虽简单，但其机制的后果却很复杂。基因水平变化导致的综合征表现会极大影响骨质，最终影响任何治疗的预后。因此，更好地理解骨重塑的分子机制有助于确定骨骼疾病的致病原因，并推动针对这些疾病的靶向治疗的发展。本综述重点阐述了科学与遗传学之间的联系，以及基因可能引发变化导致畸形的各种口腔情况。未来有待深入研究，以干预引发基因调控的原因，从而降低人类死亡率。
