F Nahhas Alaa, F Nahhas Alrayan, J Webster Thomas
Biochemistry Department, College of Science, King Abdulaziz University, Jeddah 21589, KSA.
Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA 02115, USA.
Nanomedicine (Lond). 2021 Jun;16(14):1237-1254. doi: 10.2217/nnm-2020-0447. Epub 2021 May 14.
Viral infections are historically very difficult to treat. Although imperfect and time-consuming to develop, we do have some conventional vaccine and therapeutic approaches to stop viral spreading. Most importantly, all of this takes significant time while viruses continue to wreak havoc on our healthcare system. Furthermore, viral infections are accompanied by a weakened immune system which is often overlooked in antiviral drug strategies and requires additional drug development. In this review, for the first time, we touch on some promising alternative approaches to treat viral infections, specifically those focused on the use of platform nanomaterials with antiviral peptides. In doing so, this review presents a timely discussion of how we need to change our old way of treating viruses into one that can quickly meet the demands of COVID-19, as well as future pandemic-causing viruses, which will come.
从历史上看,病毒感染很难治疗。尽管开发过程不完善且耗时,但我们确实有一些传统的疫苗和治疗方法来阻止病毒传播。最重要的是,所有这些都需要大量时间,而病毒却继续在我们的医疗系统中肆虐。此外,病毒感染会伴随着免疫系统的减弱,这在抗病毒药物策略中常常被忽视,需要进一步开发药物。在本综述中,我们首次探讨了一些有前景的治疗病毒感染的替代方法,特别是那些专注于使用带有抗病毒肽的平台纳米材料的方法。这样做的同时,本综述适时地讨论了我们如何需要将治疗病毒的旧方法转变为能够迅速满足新冠疫情以及未来将会出现的大流行病毒需求的方法。