Institute of Ophthalmology, University College London, London, EC1V 9EL, UK.
NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, London, UK.
Sci Rep. 2021 May 14;11(1):10349. doi: 10.1038/s41598-021-89677-4.
To evaluate the effect of aging, intra- and intersession repeatability and regional scotopic sensitivities in healthy and age-related macular degeneration (AMD) eyes. Intra- and intersession agreement and effect of age was measured in healthy individuals. The mean sensitivity (MS) and pointwise retinal sensitivities (PWS) within the central 24° with 505 nm (cyan) and 625 nm (red) stimuli were evaluated in 50 individuals (11 healthy and 39 AMD eyes). The overall intra- and intersession had excellent reliability (intraclass correlation coefficient, ICC > 0.90) and tests were highly correlated (Spearman r = 0.75-0.86). Eyes with subretinal drusenoid deposit (SDD) had reduced PWS centrally, particularly at inferior and nasal retinal locations compared with controls and intermediate AMD (iAMD) without SDD. There was no difference in MS or PWS at any retinal location between iAMD without SDD and healthy individuals nor between iAMD with SDD and non-foveal atrophic AMD groups. Eyes with SDD have reduced rod function compared to iAMD without SDD and healthy eyes, but similar to eyes with non-foveal atrophy. Our results highlight rod dysfunction is not directly correlated with drusen load and SDD location.
评估健康人和年龄相关性黄斑变性（AMD）眼中衰老、内和间测试重复性以及暗视区敏感性的影响。在健康个体中测量了内和间测试的一致性和年龄的影响。在 50 名个体（11 名健康和 39 只 AMD 眼）中评估了中央 24°内用 505nm（青色）和 625nm（红色）刺激的平均敏感性（MS）和点视网膜敏感性（PWS）。整体内和间测试具有极好的可靠性（组内相关系数，ICC>0.90），测试高度相关（Spearman r=0.75-0.86）。与对照组和无 SDD 的中间型 AMD（iAMD）相比，具有视网膜下类脂沉积（SDD）的眼在中央部位的 PWS 降低，特别是在下方和鼻侧视网膜部位。在任何视网膜部位，无 SDD 的 iAMD 与健康个体之间，以及有 SDD 的 iAMD 与非中心凹萎缩性 AMD 组之间，MS 或 PWS 均无差异。与无 SDD 的 iAMD 和健康眼相比，有 SDD 的眼的杆状功能降低，但与无中心凹萎缩的眼相似。我们的结果强调了杆状功能障碍与玻璃膜疣负荷和 SDD 位置没有直接相关性。
