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BNT162b2 信使 RNA 疫苗未能预防老年疗养院严重急性呼吸综合征冠状病毒 2 变异株 501Y.V2 的爆发，但降低了传播和疾病严重程度。

BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity.

机构信息

Department of Infectious Disease, University Hospital of Besançon, Besançon, France.

Department of Infectious Disease, Hospital of Lons Le Saunier, Lons Le Saunier, France.

出版信息

Clin Infect Dis. 2022 Feb 11;74(3):517-520. doi: 10.1093/cid/ciab446.

DOI:10.1093/cid/ciab446
PMID:33993228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8241482/
Abstract

We report an outbreak of severe acute respiratory syndrome coronavirus 2 501Y.V2 in a nursing home. All nonvaccinated residents (5/5) versus half of those vaccinated with BNT162b2 (13/26) were infected. Two of 13 vaccinated versus 4 of 5 nonvaccinated residents presented severe disease. BNT162b2 did not prevent the outbreak, but reduced transmission and disease severity.

摘要

我们报告了一起严重急性呼吸综合征冠状病毒 2 501Y.V2 在一家养老院的爆发。所有未接种疫苗的居民（5/5）与接种 BNT162b2 的居民的一半（13/26）相比都被感染了。在接种疫苗的 13 人中，有 2 人出现严重疾病，而在未接种疫苗的 5 人中，有 4 人出现严重疾病。BNT162b2 并未阻止此次爆发，但降低了传播和疾病的严重程度。