VAV1 基因多态性与肾移植排斥反应有关。

VAV1 Gene Polymorphism is Associated With Kidney Allograft Rejection.

机构信息

Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.

Department of Physiology, Pomeranian Medical University, Szczecin, Poland.

出版信息

Transplant Proc. 2021 Jun;53(5):1528-1531. doi: 10.1016/j.transproceed.2021.04.003. Epub 2021 May 14.

DOI:10.1016/j.transproceed.2021.04.003

PMID:33994185

Abstract

BACKGROUND

VAV1 is an intracellular signal transduction protein that plays a significant role in signal transduction in T cells. Several studies suggest that VAV1 signaling plays significant roles in allograft rejection. The aim of this study was to examine the association between VAV1 gene polymorphisms and renal allograft function.

METHODS

The study included 270 patients after allograft renal transplantation. We examined the associations between VAV1 gene polymorphisms and complications after transplantation, such as delayed graft function, acute rejection, and chronic allograft dysfunction.

RESULTS

There were no statistically significant associations between VAV1 genotypes and delayed graft function and chronic allograft dysfunction. Among patients with acute allograft rejection, we observed decreased frequencies of VAV1 rs2546133 TT and CT genotypes (P = .03) and T allele (P = .02), as well as VAV1 rs2617822 GG and AG genotypes (P = .05) and G allele (P = 0.04). In the multivariate regression analysis, the higher number of VAV1 rs2546133 T alleles showed a protective effect against the acute rejection in kidney allograft recipients.

CONCLUSIONS

The results of our study suggest that polymorphisms in the VAV1 gene are associated with kidney allograft rejection.

摘要

背景

VAV1 是一种细胞内信号转导蛋白，在 T 细胞信号转导中发挥重要作用。多项研究表明，VAV1 信号在同种异体移植物排斥中发挥着重要作用。本研究旨在探讨 VAV1 基因多态性与肾移植后肾功能的关系。

方法

该研究纳入了 270 例肾移植后患者。我们研究了 VAV1 基因多态性与移植后并发症（如延迟移植物功能、急性排斥和慢性移植物功能障碍）之间的关系。

结果

VAV1 基因型与延迟移植物功能和慢性移植物功能障碍之间无统计学显著相关性。在急性移植物排斥患者中，我们观察到 VAV1 rs2546133 TT 和 CT 基因型（P=.03）和 T 等位基因（P=.02）以及 VAV1 rs2617822 GG 和 AG 基因型（P=.05）和 G 等位基因（P=0.04）的频率降低。在多变量回归分析中，VAV1 rs2546133 等位基因数量较高与肾移植受者急性排斥反应具有保护作用。