新冠病毒感染期间转移性结直肠癌患者出现意外的肿瘤缩小情况。
Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection.
作者信息
Ottaiano Alessandro, Scala Stefania, D'Alterio Crescenzo, Trotta Annamaria, Bello Annamaria, Rea Giuseppina, Picone Carmine, Santorsola Mariachiara, Petrillo Antonella, Nasti Guglielmo
机构信息
SSD-Innovative Therapies for Abdominal Metastases, Department of Abdominal Oncology, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' via M. Semmola, Naples 80131, Italy.
Microenvironment Molecular Targets, Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale,' Naples, Italy.
出版信息
Ther Adv Med Oncol. 2021 Apr 29;13:17588359211011455. doi: 10.1177/17588359211011455. eCollection 2021.
Herein, we describe three patients affected by metastatic colorectal cancer (mCRC) experiencing infection by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and reduction of disease burden during coronavirus disease 2019 (COVID-19) course. Insights into tumor-associated angiotensin-converting enzyme (ACE)-2 expression and lymphocyte function suggest a correlation between host/SARS-Cov-2 infection and tumor burden reduction. This may shed new light into (a) the infection mechanism of SARS-CoV-2 virus and (b) the multiple aspects of a composite antiviral immune response with potential paradoxical and unexpected applications.
在此，我们描述了三名转移性结直肠癌（mCRC）患者，他们在2019冠状病毒病（COVID-19）病程中感染了严重急性呼吸综合征冠状病毒2（SARS-CoV-2），且疾病负担减轻。对肿瘤相关血管紧张素转换酶（ACE）-2表达和淋巴细胞功能的深入研究表明，宿主/SARS-CoV-2感染与肿瘤负担减轻之间存在关联。这可能为（a）SARS-CoV-2病毒的感染机制以及（b）具有潜在矛盾和意外应用的复合抗病毒免疫反应的多个方面提供新的线索。
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