Xu Xiao, Han Chao, Zhang Can, Yan Dan, Ren Chunling, Kong Lingyi
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
State Key Laboratory of Natural Medicines, Center of Drug Discovery and Department of Pharmaceutics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Theranostics. 2021 Apr 19;11(13):6477-6490. doi: 10.7150/thno.55708. eCollection 2021.
: Integration of several monotherapies into a single nanosystem can produce remarkable synergistic antitumor effects compared with separate delivery of combination therapies. We developed near-infrared (NIR) light-triggered nanoparticles that induce a domino effect for multimodal tumor therapy. : The designed intelligent phototriggered nanoparticles (IPNs) were composed of a copper sulfide-loaded upconversion nanoparticle core, a thermosensitive and photosensitive enaminitrile molecule (EM) organogel shell loaded with anticancer drugs, and a cancer cell membrane coating. Irradiation with an NIR laser activated a domino effect beginning with photothermal generation by copper sulfide for photothermal therapy that also resulted in phase transformation of the EM gel to release the anticancer drug. Meanwhile, the NIR light energy was converted to ultraviolet light by the upconversion core to excite the EM, which generated reactive oxygen species for photodynamic therapy. : IPNs achieved excellent antitumor effects and with little systemic toxicity, indicating that IPNs could serve as a safe and high-performance instrument for synergetic antitumor therapy. : This intelligent drug delivery system induced a chain reaction generating multiple antitumor therapies after a single stimulus.
与联合疗法的单独给药相比，将几种单一疗法整合到单个纳米系统中可产生显著的协同抗肿瘤作用。我们开发了近红外（NIR）光触发的纳米颗粒，可诱导多米诺效应以进行多模式肿瘤治疗。：所设计的智能光触发纳米颗粒（IPN）由负载硫化铜的上转换纳米颗粒核心、负载抗癌药物的热敏和光敏烯胺腈分子（EM）有机凝胶壳以及癌细胞膜涂层组成。用近红外激光照射激活了多米诺效应，首先是硫化铜产生光热用于光热治疗，这也导致EM凝胶发生相变以释放抗癌药物。同时，近红外光能被上转换核心转换为紫外光以激发EM，后者产生活性氧用于光动力治疗。：IPN实现了优异的抗肿瘤效果且全身毒性很小，表明IPN可作为协同抗肿瘤治疗的安全且高性能的工具。：这种智能药物递送系统在单一刺激后诱导产生连锁反应，产生多种抗肿瘤疗法。
