Tucić Milena, Stamenković Vera, Andjus Pavle
Center for Laser Microscopy, Institute for Physiology and Biochemistry "Jean Giaja", Faculty of Biology, University of Belgrade, Belgrade, Serbia.
Front Cell Dev Biol. 2021 Apr 29;9:674199. doi: 10.3389/fcell.2021.674199. eCollection 2021.
Tenascin C (TnC) is a glycoprotein highly expressed in the extracellular matrix (ECM) during development and in the adult central nervous system (CNS) in regions of active neurogenesis, where neuron development is a tightly regulated process orchestrated by extracellular matrix components. In addition, newborn cells also communicate with glial cells, astrocytes and microglia, indicating the importance of signal integration in adult neurogenesis. Although TnC has been recognized as an important molecule in the regulation of cell proliferation and migration, complete regulatory pathways still need to be elucidated. In this review we discuss the formation of new neurons in the adult hippocampus and the olfactory system with specific reference to TnC and its regulating functions in this process. Better understanding of the ECM signaling in the niche of the CNS will have significant implications for regenerative therapies.
腱生蛋白C（TnC）是一种糖蛋白，在发育过程中的细胞外基质（ECM）以及成年中枢神经系统（CNS）中活跃神经发生的区域高度表达，在这些区域，神经元发育是一个由细胞外基质成分精心调控的严格过程。此外，新生细胞还与神经胶质细胞、星形胶质细胞和小胶质细胞进行交流，这表明信号整合在成体神经发生中的重要性。尽管TnC已被认为是调节细胞增殖和迁移的重要分子，但其完整的调控途径仍有待阐明。在这篇综述中，我们将特别参考TnC及其在此过程中的调节功能，讨论成年海马体和嗅觉系统中新神经元的形成。更好地理解中枢神经系统生态位中的细胞外基质信号传导，将对再生疗法产生重大影响。
