Guo Shuren, Mao Xiaohuan, Li Xiaohua, Ouyang Huan, Gao Yuhua, Ming Liang
Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Department of Clinical Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Front Cardiovasc Med. 2021 Apr 29;8:618173. doi: 10.3389/fcvm.2021.618173. eCollection 2021.
Complement C1q plays a dual role in the atherosclerosis. Previous studies showed inconsistent results about the association of serum C1q levels and coronary artery disease (CAD). Here, we explored the associations of serum C1q activity with CAD, coronary stenosis severity, cardiovascular biomarkers, and 1-year restenosis after coronary artery revascularization. We enrolled 956 CAD patients and 677 controls to evaluate the associations of serum complement C1q activity to the presence and severity of obstructive CAD and non-obstructive CAD. Serum C1q activity and the concentrations of laboratory markers were measured in all subjects. All the data were analyzed using SPSS22.0 software. Serum C1q activity in Obstructive CAD and Non-Obstructive CAD groups was significantly higher than the control group (195.52 ± 48.31 kU/L and 195.42 ± 51.25 kU/L vs. 183.44 ± 31.75 kU/L, < 0.05). Greater C1q activity was significantly correlated with higher total cholesterol (TC) and triglyceride (TG) levels. C1q activity was associated with an increased Odds Ratio (OR) of CAD (OR = 1.322, 95% CI 1.168-1.496, < 0.05) and 1-year restenosis after revascularization (the highest OR = 3.544, 95% CI 1.089-12.702, < 0.05). Complement C1q activity was not correlated with Gensini score in the Obstructive CAD group after adjustment for confounders. C1q activity has low value in predicting the incidence of CAD. Serum complement C1q activity is associated with obstructive CAD.
补体C1q在动脉粥样硬化中起双重作用。先前的研究关于血清C1q水平与冠状动脉疾病（CAD）的关联得出了不一致的结果。在此，我们探讨了血清C1q活性与CAD、冠状动脉狭窄严重程度、心血管生物标志物以及冠状动脉血运重建术后1年再狭窄的关联。我们纳入了956例CAD患者和677例对照，以评估血清补体C1q活性与阻塞性CAD和非阻塞性CAD的存在及严重程度之间的关联。在所有受试者中测量了血清C1q活性和实验室标志物的浓度。所有数据均使用SPSS22.0软件进行分析。阻塞性CAD组和非阻塞性CAD组的血清C1q活性显著高于对照组（分别为195.52±48.31 kU/L和195.42±51.25 kU/L，对比183.44±31.75 kU/L，P<0.05）。更高的C1q活性与更高的总胆固醇（TC）和甘油三酯（TG）水平显著相关。C1q活性与CAD的比值比（OR）增加相关（OR = 1.322，95%可信区间1.168 - 1.496，P<0.05）以及血运重建术后1年再狭窄相关（最高OR = 3.544，95%可信区间1.089 - 12.702，P<0.05）。在调整混杂因素后，阻塞性CAD组中补体C1q活性与Gensini评分不相关。C1q活性在预测CAD发病率方面价值较低。血清补体C1q活性与阻塞性CAD相关。
