Wu Cheng-Long, Yin Ran, Wang Su-Nan, Ying Ru
Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Front Cardiovasc Med. 2021 Apr 28;8:674498. doi: 10.3389/fcvm.2021.674498. eCollection 2021.
Chemokine C-X-C motif ligand-1 (CXCL1), principally expressed in neutrophils, macrophages and epithelial cells, is a valid pro-inflammatory factor which performs an important role in mediating the infiltration of neutrophils and monocytes/macrophages. Elevated serum level of CXCL1 is considered a pro-inflammatory reaction by the organism. CXCL1 is also related to diverse organs fibrosis according to relevant studies. A growing body of evidence suggests that CXCL1 promotes the process of cardiac remodeling and fibrosis. Here, we review structure and physiological functions of CXCL1 and recent progress on the effects and mechanisms of CXCL1 in cardiac fibrosis. In addition, we explore the role of CXCL1 in the fibrosis of other organs. Besides, we probe the possibility that CXCL1 can be a therapeutic target for the treatment of cardiac fibrosis in cardiovascular diseases.
趋化因子C-X-C基序配体1（CXCL1）主要在中性粒细胞、巨噬细胞和上皮细胞中表达，是一种有效的促炎因子，在介导中性粒细胞和单核细胞/巨噬细胞浸润中发挥重要作用。血清CXCL1水平升高被认为是机体的一种促炎反应。根据相关研究，CXCL1还与多种器官纤维化有关。越来越多的证据表明，CXCL1促进心脏重塑和纤维化进程。在此，我们综述CXCL1的结构和生理功能，以及CXCL1在心脏纤维化中的作用和机制的最新进展。此外，我们探讨CXCL1在其他器官纤维化中的作用。此外，我们探究CXCL1作为心血管疾病中治疗心脏纤维化的治疗靶点的可能性。
