Mohana Devi S, Mahalaxmi I, Kaavya J, Chinnkulandhai V, Balachandar V
SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, 41/18, College Road, Chennai, 600006, India.
Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Avinashilingam University for Women, Coimbatore, Tamil Nadu, 641046, India.
Genes Dis. 2020 Jan 23;8(3):279-286. doi: 10.1016/j.gendis.2020.01.003. eCollection 2021 May.
Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism. They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression. DNA methylation is the earliest discovered epigenetic alteration. In this review, we try to examine the role of DNA methylation and histone modification in Age related macular degeneration (AMD) and Diabetic Retinopathy (DR), its vascular complications and recent progress. Given the complex nature of AMD and DR, it is crucial to improve therapeutics which will greatly enhance the quality of life and reduce the burden for millions of patients living with these potentially blinding conditions.
表观遗传机制在基因表达调控中发挥着重要作用，这些改变可能会诱导基因功能和代谢的长期变化。它们通过对基因表达的影响，在弥合环境暴露与疾病发展之间的差距方面受到了广泛关注。DNA甲基化是最早发现的表观遗传改变。在本综述中，我们试图探讨DNA甲基化和组蛋白修饰在年龄相关性黄斑变性（AMD）和糖尿病视网膜病变（DR）及其血管并发症中的作用以及最新进展。鉴于AMD和DR的复杂性，改进治疗方法至关重要，这将极大地提高数百万患有这些潜在致盲疾病患者的生活质量并减轻其负担。
