Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Mol Med. 2023 Feb 27;29(1):28. doi: 10.1186/s10020-023-00624-7.
Vascular aging is an inevitable process with advancing age, which plays a crucial role in the pathogenesis of cardiovascular and microvascular diseases. Diabetic retinopathy (DR) and age-related macular degeneration (AMD), characterized by microvascular dysfunction, are the common causes of irreversible blindness worldwide, however there is still a lack of effective therapeutic strategies for rescuing the visual function. In order to develop novel treatments, it is essential to illuminate the pathological mechanisms underlying the vascular aging during DR and AMD progression. In this review, we have summarized the recent discoveries of the effects of oxidative stress and epigenetics on microvascular degeneration, which could provide potential therapeutic targets for DR and AMD.
血管老化是随着年龄增长而不可避免的过程，它在心血管和微血管疾病的发病机制中起着关键作用。糖尿病视网膜病变 (DR) 和年龄相关性黄斑变性 (AMD) 以微血管功能障碍为特征，是全球范围内导致不可逆转失明的常见原因，但目前仍缺乏有效的治疗策略来挽救视力。为了开发新的治疗方法，阐明 DR 和 AMD 进展过程中血管老化的病理机制至关重要。在这篇综述中，我们总结了氧化应激和表观遗传学对微血管退化影响的最新发现，这些发现可能为 DR 和 AMD 提供潜在的治疗靶点。
