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用于骨修复的3D打印掺锌介孔二氧化硅复合聚-L-乳酸支架

3D Printed Zn-doped Mesoporous Silica-incorporated Poly-L-lactic Acid Scaffolds for Bone Repair.

作者信息

Qian Guowen, Zhang Lemin, Wang Guoyong, Zhao Zhengyu, Peng Shuping, Shuai Cijun

机构信息

Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China.

Shenzhen Institute of Information Technology, Shenzhen 518172, China.

出版信息

Int J Bioprint. 2021 Mar 10;7(2):346. doi: 10.18063/ijb.v7i2.346. eCollection 2021.

DOI:10.18063/ijb.v7i2.346
PMID:33997435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8114096/
Abstract

Poly-L-lactic acid (PLLA) lacks osteogenic activity, which limits its application in bone repair. Zinc (Zn) is widely applied to strengthen the biological properties of polymers due to its excellent osteogenic activity. In the present study, Zn-doped mesoporous silica (Zn-MS) particles were synthesized by one-pot hydrothermal method. Then, the particles were induced into PLLA scaffolds prepared by selective laser sintering technique, aiming to improve their osteogenic activity. Our results showed that the synthesized particles possessed rosette-like morphology and uniform mesoporous structure, and the composite scaffold displayed the sustained release of Zn ion in a low concentration range, which was attributed to the shield effect of the PLLA matrix and the strong bonding interaction of Si-O-Zn. The scaffold could evidently promote osteogenesis differentiation of mouse bone marrow mesenchymal stem cells by upregulating their osteogenesis-related gene expression. Besides, Zn-MS particles could significantly increase the compressive strength of the PLLA scaffold because of their rosette-like morphology and mesoporous structure, which can form micromechanical interlocking with the PLLA matrix. The Zn-MS particles possess great potential to improve various polymer scaffold properties due to their advantageous morphology and physicochemical properties.

摘要

聚左旋乳酸（PLLA）缺乏成骨活性，这限制了其在骨修复中的应用。锌（Zn）因其出色的成骨活性而被广泛应用于增强聚合物的生物学性能。在本研究中，通过一锅水热法合成了掺锌介孔二氧化硅（Zn-MS）颗粒。然后，将这些颗粒引入通过选择性激光烧结技术制备的PLLA支架中，旨在提高其成骨活性。我们的结果表明，合成的颗粒具有玫瑰花状形态和均匀的介孔结构，并且复合支架在低浓度范围内显示出锌离子的持续释放，这归因于PLLA基质的屏蔽效应和Si-O-Zn的强键合相互作用。该支架可通过上调其成骨相关基因表达明显促进小鼠骨髓间充质干细胞的成骨分化。此外，Zn-MS颗粒由于其玫瑰花状形态和介孔结构可与PLLA基质形成微机械互锁，从而可显著提高PLLA支架的抗压强度。由于其有利的形态和物理化学性质，Zn-MS颗粒在改善各种聚合物支架性能方面具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e546/8114096/e084fa08b76e/IJB-7-2-346-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e546/8114096/e084fa08b76e/IJB-7-2-346-g008.jpg
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