Bezdetnaia L N, Nagiev A I, Potapenko A Ia
Vopr Med Khim. 1988 Mar-Apr;34(2):56-9.
Hemolysis of erythrocytes was induced after addition of ethanol solution of photooxidized psoralen, while the substance irradiated in absence of oxygen did not cause the cells hemolysis. The rate of hemolysis correlated with concentration of photooxidized psoralen in a sigmoid type. Similar concentration-dependent effect has been known for digitonin. Digitonin elevated the ionic permeability of lecithin-cholesterol liposomes but did not affect the permeability of lecithin liposomes. Photooxidized psoralen did not effect apparently on liposomes of both types. These data suggest that hemolytic effect of photooxidized psoralen did not relate to the substance interaction with cholesterol.
加入光氧化补骨脂素的乙醇溶液后可诱导红细胞溶血，而在无氧条件下照射的该物质不会引起细胞溶血。溶血速率与光氧化补骨脂素的浓度呈S形相关。洋地黄皂苷也有类似的浓度依赖性效应。洋地黄皂苷可提高卵磷脂-胆固醇脂质体的离子通透性，但不影响卵磷脂脂质体的通透性。光氧化补骨脂素对这两种类型的脂质体均无明显影响。这些数据表明，光氧化补骨脂素的溶血作用与该物质和胆固醇的相互作用无关。
