[Fe2+离子对补骨脂素光氧化产物诱导的溶血作用]
[Effect of Fe2+ ions on the hemolysis induced by products of psoralen photo-oxidation].
作者信息
Zhuravel' N N, Belichenko I V, Kiagova A A, Lysenko E P, Khalilov E M, Potapenko A Ia
出版信息
Biofizika. 1997 Jan-Feb;42(1):182-6.
PMID:9181789
Abstract
The effects of Fe2+ ions on haemolysis induced by previously photooxidized psoralen (POP-haemolysis) were investigated. It was shown that POP-haemolysis was strongly activated by Fe2+ ions when ferrous ions were added to erythrocytes just after addition of POP. If POP was preincubated with Fe2+ before mixing with erythrocytes, then POP completely lost its ability to induce haemolysis. These data indicate the peroxidic nature of POP products responsible for haemolysis.
摘要
研究了Fe2+离子对先前光氧化补骨脂素诱导的溶血作用（POP溶血）的影响。结果表明，当在加入POP后立即向红细胞中加入亚铁离子时，POP溶血被Fe2+离子强烈激活。如果在与红细胞混合之前将POP与Fe2+预孵育，那么POP完全失去其诱导溶血的能力。这些数据表明导致溶血的POP产物具有过氧化物性质。
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