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药物递送系统(DDS)的新范式:空间、时间和形状方面的挑战。

A New Paradigm of Pharmaceutical Drug Delivery Systems (DDS): Challenges for Space, Time, and Shapes.

作者信息

Eo Jaeseok, Cepeda Brandon, Kim Jihye, Kim Namsoo

机构信息

Department of Metallurgical, Materials and Biomedical Engineering, The University of Texas at El Paso, TX, USA.

Center for Printable Materials Certification (CPMC), The University of Texas at El Paso, TX, USA.

出版信息

Innov Pharm. 2018 Oct 26;9(3):1-13. doi: 10.24926/iip.v9i3.1450. eCollection 2018.


DOI:10.24926/iip.v9i3.1450
PMID:34007712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6302755/
Abstract

Using 3D food printing with the Internet of Things (IoT) technology, patients can receive diagnoses and prescriptions from their doctors while in the comfort of their homes. The patient-specific prescription has been innovated by converging 3D food printing technology with drug delivery systems (DDSs). Quantitative drug dosages can be incorporated into the composition of food and produced in any shape within a short time. Automating food and DDSs makes promising implications for healing patients remotely, as well. Each of these aspects, along with IoT technology, have contributed to increased health care for patients, no matter their location. The quantitative discharge of vitamin C melted in water, mayonnaise, ketchup, and peanut butter has been verified using the Piston Typed Extrusion (PTE) method. Designs with different curves and shapes were repeatedly printed with a head speed of 1.6×10 m/s, and it was confirmed that effective control while printing the shapes was possible. The Hagen-Poiseuille (HP) formula was utilized to simulate the overall printing time. This simulation affirmed that increasing the head speed from 1.6×10 m/s to 4.0×10 m/s had reduced the printing time consistently, but the time was not reduced continuously after 4.0×10 m/s, depending on the materials' viscosities and how much curvature exists in the designs. The precision of printing was adjusted within 5% of the theoretical value during printing, and the IoT technology allowed printing of the materials within five minutes, regardless of the patient's location.

摘要

通过将3D食品打印与物联网(IoT)技术相结合,患者可以在舒适的家中接受医生的诊断和处方。通过将3D食品打印技术与药物递送系统(DDS)相结合,创新了针对患者的特定处方。定量药物剂量可以融入食品成分中,并在短时间内制成任何形状。食品和DDS的自动化对于远程治疗患者也具有广阔的前景。这些方面中的每一个,连同物联网技术,都为患者提供了更多的医疗保健,无论他们身在何处。使用活塞式挤出(PTE)方法已经验证了维生素C在水、蛋黄酱、番茄酱和花生酱中的定量释放。以1.6×10米/秒的喷头速度反复打印具有不同曲线和形状的设计,并确认在打印形状时能够进行有效控制。利用哈根-泊肃叶(HP)公式模拟整个打印时间。该模拟证实,将喷头速度从1.6×10米/秒提高到4.0×10米/秒持续减少了打印时间,但在4.0×10米/秒之后,时间并非持续减少,这取决于材料的粘度以及设计中的曲率大小。在打印过程中,打印精度在理论值的5%以内进行调整,并且物联网技术允许在五分钟内打印材料,无论患者身在何处。

相似文献

[1]
A New Paradigm of Pharmaceutical Drug Delivery Systems (DDS): Challenges for Space, Time, and Shapes.

Innov Pharm. 2018-10-26

[2]
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本文引用的文献

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Int J Pharm. 2017-11-9

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J Control Release. 2014-9-28

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Microfabricated microneedles: a novel approach to transdermal drug delivery.

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