Visca A, Castello M, Castello D
Divisione di Pneumologia, Ospedale Infantile Regina Margherita, Torino.
Minerva Pediatr. 1994 May;46(5):245-9.
Pressler et al. (1988) showed a correlation between elevated serum levels of IgG2 and IgG3 with decreased lung function. We tried to verify that hypothesis and to evaluate the usefulness of IgG subclasses as prognostic markers in 54 cystic fibrosis patients. The serum levels of the IgG subclasses were determined by radial immunodiffusion and correlated to Vital capacity (VC), obtained with a bell spirometer (Biomedin), and to oxyhemoglobin saturation (SaO2), obtained with a pulse oximeter (Minolta Pulsox 7). For statistical analysis, Student's "t" test, Pearson's chi-square and multiple regression were used. Significance was accepted at p < 0.05. We found significant correlation between elevated serum levels of IgG1 and decreased VC (r = -0.53; p < 0.01), and between high levels of IgG1 and decreased SaO2 (r = -0.45; p < 0.01). Elevated serum levels of IgG1 are significantly correlated with high levels of IgG2 (r = 0.41; p < 0.05) and with high levels of IgG4 (r = 0.43; p < 0.05). There is significant correlation between the increase in IgG4 and SaO2 impairment (r = 0.51; p < 0.01), but no significant correlation between IgG4 and VC was found. Patients with elevated serum levels of IgG1 had significantly lower VC than patients with IgG1 below the normal range (p < 0.002). No difference in VC was found, when comparing patients with low and high levels of the other subclasses.(ABSTRACT TRUNCATED AT 250 WORDS)
普雷斯勒等人（1988年）指出，血清中IgG2和IgG3水平升高与肺功能下降之间存在关联。我们试图验证这一假设，并评估IgG亚类作为54例囊性纤维化患者预后标志物的效用。通过放射免疫扩散法测定IgG亚类的血清水平，并将其与用钟形肺活量计（Biomedin）测得的肺活量（VC）以及用脉搏血氧仪（美能达Pulsox 7）测得的氧合血红蛋白饱和度（SaO2）进行关联分析。采用学生t检验、皮尔逊卡方检验和多元回归进行统计分析。当p<0.05时认为具有统计学意义。我们发现血清IgG1水平升高与VC降低之间存在显著相关性（r = -0.53；p<0.01），以及高水平的IgG1与SaO2降低之间存在显著相关性（r = -0.45；p<0.01）。血清IgG1水平升高与高水平的IgG2（r = 0.41；p<0.05）和高水平的IgG4（r = 0.43；p<0.05）显著相关。IgG4升高与SaO2损害之间存在显著相关性（r = 0.51；p<0.01），但未发现IgG4与VC之间存在显著相关性。血清IgG1水平升高的患者的VC显著低于IgG1水平在正常范围以下的患者（p<0.002）。比较其他亚类水平低和高的患者时，未发现VC有差异。（摘要截选至250字）
