基于金属有机骨架的结构依赖性比率荧光传感器用于检测 2,6-吡啶二甲酸。

A structure-dependent ratiometric fluorescence sensor based on metal-organic framework for detection of 2,6-pyridinedicarboxylic acid.

机构信息

Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 211198, China.

Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing, 211198, China.

出版信息

Anal Bioanal Chem. 2021 Jul;413(16):4227-4236. doi: 10.1007/s00216-021-03369-6. Epub 2021 May 19.

DOI:10.1007/s00216-021-03369-6

PMID:34009443

Abstract

In the present work, a structure-dependent ratiometric fluorescence (RF) sensor constructed with boric acid-modified carbon quantum dots (B-CQDs) and Tb-MOF(MOF-76) was developed for sensing 2,6-pyridinedicarboxylic acid (DPA). Based on the distinct fluorescent responses of B-CQDs and MOF-76 to DPA, MOF-76/B-CQDs can be developed as a RF sensor for DPA detection. In this RF sensor, the reticulated cross-linked structure of MOF-76/B-CQDs can be destroyed by DPA due to a strong coordination effect between DPA and the Tb of MOF-76, resulting in the quenching of the fluorescence of B-CQD and the restoration of the fluorescence of MOF-76 after the addition of DPA. Benefiting from the confinement effect of the special structure change, the presented sensor showed high sensitivity toward DPA with a detection limit of 3.05 μM and excellent selectivity over the monochromatic fluorescence sensor.

摘要

在本工作中，构建了一种基于硼酸修饰的碳量子点（B-CQDs）和 Tb-MOF（MOF-76）的结构依赖型比率荧光（RF）传感器，用于检测 2,6-吡啶二甲酸（DPA）。基于 B-CQDs 和 MOF-76 对 DPA 的明显荧光响应，MOF-76/B-CQDs 可被开发为用于 DPA 检测的 RF 传感器。在该 RF 传感器中，由于 DPA 与 MOF-76 的 Tb 之间的强配位作用，MOF-76/B-CQDs 的网状交联结构会被 DPA 破坏，导致 B-CQD 的荧光猝灭，并且在加入 DPA 后 MOF-76 的荧光恢复。受益于特殊结构变化的限制效应，与单色谱荧光传感器相比，该传感器对 DPA 表现出高灵敏度，检测限为 3.05 μM，具有优异的选择性。