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基于UiO-66-NH的荧光传感用于检测牛奶中的四环素。

UiO-66-NH based fluorescent sensing for detection of tetracyclines in milk.

作者信息

Wang Xiaohui, Wang Xufeng

机构信息

State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology Tianjin 300457 China

出版信息

RSC Adv. 2022 Aug 17;12(36):23427-23436. doi: 10.1039/d2ra04023a. eCollection 2022 Aug 16.

DOI:10.1039/d2ra04023a
PMID:36090428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9382652/
Abstract

In this work, a fluorescent sensor based on a zirconium-based metal organic framework was prepared for the detection of tetracyclines (TCs) in milk. The UiO-66-NH fluorescent sensor was synthesized by a simple microwave-assisted method with 2-aminoterephthalic acid and zirconium chloride as precursors. In the presence of target TCs, the synergistic effect of the inner filter effect (IFE) and photo-induced electron transfer (PET) was responsible for the fluorescence quenching of UiO-66-NH, and the fluorescence sensor showed a rapid fluorescence quenching response (5 min) to target TCs. The proposed UiO-66-NH sensor had good sensitivity and selectivity, and under the optimal conditions possessed detection limits of 0.449, 0.431, and 0.163 μM for tetracycline (TET), oxytetracycline (OTC), and doxycycline (DOX), respectively. Besides, the UiO-66-NH sensor was successfully applied to the quantitative detection of TCs in milk samples with reasonable recoveries of 93.26-115.17%, and the detection results achieved from the as-fabricated fluorescence sensing assay were consistent with those of high-performance liquid chromatography (HPLC), indicating the potential applicability of the UiO-66-NH sensor for detecting TCs in actual food samples.

摘要

在这项工作中，制备了一种基于锆基金属有机框架的荧光传感器，用于检测牛奶中的四环素（TCs）。以2-氨基对苯二甲酸和氯化锆为前驱体，通过简单的微波辅助法合成了UiO-66-NH荧光传感器。在目标TCs存在的情况下，内滤效应（IFE）和光致电子转移（PET）的协同作用导致UiO-66-NH的荧光猝灭，该荧光传感器对目标TCs表现出快速的荧光猝灭响应（5分钟）。所提出的UiO-66-NH传感器具有良好的灵敏度和选择性，在最佳条件下，对四环素（TET）、土霉素（OTC）和强力霉素（DOX）的检测限分别为0.449、0.431和0.163μM。此外，UiO-66-NH传感器成功应用于牛奶样品中TCs的定量检测，回收率在93.26%-115.17%之间，所制备的荧光传感分析方法的检测结果与高效液相色谱（HPLC）的结果一致，表明UiO-66-NH传感器在实际食品样品中检测TCs具有潜在的适用性。

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