College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, P. R. China.
Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
Chemistry. 2021 Jul 7;27(38):9737-9741. doi: 10.1002/chem.202101035. Epub 2021 May 27.
A widely applicable approach was developed to synthesize ketones, esters, amides via the oxidative C-C bond cleavage of readily available alkyl aldehydes. Green and abundant molecular oxygen (O ) was used as the oxidant, and base metals (cobalt and copper) were used as the catalysts. This strategy can be extended to the one-pot synthesis of ketones from primary alcohols and α-ketoamides from aldehydes.
研究团队开发了一种广泛适用的方法，可通过易获得的烷基醛的氧化 C-C 键断裂来合成酮、酯和酰胺。该方法使用绿色且丰富的氧气（O ）作为氧化剂，使用基础金属（钴和铜）作为催化剂。该策略可扩展到由伯醇一锅法合成酮和由醛一锅法合成α-酮酰胺。
