Department of Chemistry, China Agricultural University, Beijing 100193, China.
Org Biomol Chem. 2022 Aug 24;20(33):6554-6557. doi: 10.1039/d2ob01275h.
A cobalt-catalyzed decarboxylative oxidation of benzylic redox-active esters is described. This protocol efficiently converts secondary or primary aliphatic carboxylic acids into aromatic ketones or aldehydes. A wide range of substrates selectively reacted in good to excellent yields with broad functional group tolerance. Notably, various biologically active molecules could also work well, which indicated the synthetic application of such a methodology.
描述了钴催化的苄基氧化还原活性酯的脱羧氧化反应。该方案能高效地将仲或伯脂肪族羧酸转化为芳基酮或醛。各种底物在很宽的官能团容忍度下以良好到优异的收率选择性反应。值得注意的是，各种生物活性分子也能很好地反应，这表明了这种方法具有合成应用的潜力。
