Klimiuk P S, Taylor L, Baker R D, Jayson M I
Rheumatic Diseases Centre, University of Manchester, Hope Hospital, Salford.
Ann Rheum Dis. 1988 Jul;47(7):542-5. doi: 10.1136/ard.47.7.542.
Autonomic function assessed by tests of cardiovascular reflexes was studied in 25 patients with systemic sclerosis and 10 patients with primary Raynaud's phenomenon. A comparison was made with 13 normal healthy subjects. Significant abnormalities in the cardiovascular reflexes were found in systemic sclerosis, both in the CREST (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) variant and also in those patients with diffuse involvement. There was sympathetic and parasympathetic dysfunction. These findings suggest that autonomic neuropathy is a feature of systemic sclerosis.
通过心血管反射测试评估自主神经功能，该研究纳入了25例系统性硬化症患者和10例原发性雷诺现象患者。并与13名正常健康受试者进行了比较。在系统性硬化症患者中发现心血管反射存在显著异常，无论是CREST（钙质沉着、雷诺现象、食管运动障碍、指端硬化、毛细血管扩张）型，还是弥漫性受累患者。存在交感神经和副交感神经功能障碍。这些发现表明自主神经病变是系统性硬化症的一个特征。
