Schuckit M A
Recent Dev Alcohol. 1985;3:11-9. doi: 10.1007/978-1-4615-7715-7_2.
This paper describes a search for genetically mediated biological factors that contribute to a predisposition toward alcoholism. Healthy, nonalcoholic, drinking men aged 21 to 25 who have a close alcoholic relative were selected as the family history positive (FHP) or higher risk subjects and matched with lower risk controls (family history negative, or FHN) on demography, drinking and smoking history, and height to weight ratio. Comparisons of this higher and lower risk population revealed no significant differences in selected personality attributes, and an alcohol challenge resulted in identical patterns of blood alcohol over time. However, the FHP men developed higher levels of the first breakdown product of ethanol, acetaldehyde, after drinking, demonstrated a less intense intoxication than the FHN controls despite identical blood alcohol concentrations, and tended to show a lower amplitude of a positive brain wave sent at about 300 msec in an event-related potential paradigm. These results may be clues to help investigators identify genetic markers of a predisposition toward alcoholism.
本文描述了一项对遗传介导的生物学因素的研究，这些因素导致了对酒精中毒的易感性。选择年龄在21至25岁之间、有近亲酗酒史的健康、不酗酒的男性作为家族史阳性（FHP）或高风险受试者，并在人口统计学、饮酒和吸烟史以及身高体重比方面与低风险对照组（家族史阴性，或FHN）进行匹配。对这一高风险和低风险人群的比较显示，在选定的人格属性方面没有显著差异，并且酒精激发试验导致血液酒精含量随时间变化的模式相同。然而，FHP男性在饮酒后乙醇的第一种分解产物乙醛的水平较高，尽管血液酒精浓度相同，但与FHN对照组相比，其醉酒程度较轻，并且在事件相关电位范式中，在大约300毫秒时发出的正脑电波振幅往往较低。这些结果可能是帮助研究人员识别酒精中毒易感性遗传标记的线索。
