Zhao Zhi-Feng, Chen Mao
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of High Altitude Disease and Cardiology, People's Hospital of Tibet Autonomous Region, Lhasa 850000, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2021 May;52(3):503-509. doi: 10.12182/20210560104.
To study the value of using the cardiogenic shock (CS) stages developed by the Society of Cardiovascular Imaging and Intervention (SCAI) in predicting the mortality of CS patients in cardiac intensive care unit (CICU).
We retrospectively collected (Jan., 2011-Jan., 2018) the information of inpatients who were admitted to the CICU of West China Hospital of Sichuan University on consecutive days, and conducted analysis on those with CS. The patients were divided into groups C, D and E, according to the corresponding SCAI stages, and the primary outcome indicator was in-hospital mortality. Logistic regression was done to determine the association between SCAI staging and in-hospital mortality before and after multivariate adjustment. The receiver operating characteristic curve was used to assess the value of SCAI stages of CS in predicting in-hospital mortality.
We studies 839 CS patients who met our inclusion criteria. The proportions of patients of SCAI stages C (Classic), D (Deteriorating), and E (Extremis) were 43.3% (363 cases), 38.7% (325 cases) and 18.0% (151 cases), respectively. The unadjusted in-hospital mortality rates were 22.9% (83 cases), 44.0% (143 cases) and 53.6% (81 cases), respectively ( <0.001). The SCAI stages had an (area under the curve) of 0.640 for predicting in-hospital mortality among CS patients in CICU. After multivariate adjustment, the increased to 0.776 ( <0.001). In patients with acute coronary syndrome, the Global Registry of Acute Coronary Events (GRACE) scores had an of 0.644 for predicting in-hospital mortality, while a combination of the GRACE score with SCAI staging yielded an increased of 0.702 ( <0.001).
In CICU patients with CS, the SCAI stages of CS can be used as a stratified method for rapid assessment of disease risks upon admission. In patients with acute coronary syndrome and CS, SCAI stages combined with GRACE scores improved the ability to predict risks of death.
研究心血管影像与介入学会(SCAI)制定的心源性休克(CS)分期在预测心脏重症监护病房(CICU)中CS患者死亡率方面的价值。
我们回顾性收集了(2011年1月至2018年1月)连续入住四川大学华西医院CICU的住院患者信息,并对CS患者进行分析。根据相应的SCAI分期将患者分为C、D和E组,主要结局指标为院内死亡率。进行逻辑回归以确定多变量调整前后SCAI分期与院内死亡率之间的关联。采用受试者工作特征曲线评估CS的SCAI分期在预测院内死亡率方面的价值。
我们研究了839例符合纳入标准的CS患者。SCAI分期C(典型)、D(恶化)和E(极度)期患者的比例分别为43.3%(363例)、38.7%(325例)和18.0%(151例)。未经调整的院内死亡率分别为22.9%(83例)、44.0%(143例)和53.6%(81例)(<0.001)。SCAI分期预测CICU中CS患者院内死亡率的曲线下面积(AUC)为0.640。多变量调整后,AUC增至0.776(<0.001)。在急性冠状动脉综合征患者中,全球急性冠状动脉事件注册(GRACE)评分预测院内死亡率的AUC为0.644,而GRACE评分与SCAI分期相结合使AUC增至0.702(<0.001)。
在CICU的CS患者中,CS的SCAI分期可作为入院时快速评估疾病风险的分层方法。在急性冠状动脉综合征合并CS的患者中,SCAI分期与GRACE评分相结合提高了死亡风险预测能力。