Peking Union Medical College Hospital, Beijing, People's Republic of China.
Med Oncol. 2021 May 21;38(6):74. doi: 10.1007/s12032-021-01522-w.
Pancreatic cancer (PC) is the most lethal malignancy of the gastrointestinal tract. The poor prognosis of patients with PC is primarily due to lack of effective treatments against its progressive and metastatic behavior. Hence, figuring out the mechanisms underlying PC development and putting up with effective targeted therapies are of great significance to improve the prognosis of patients with PC. Apoptosis and autophagy serve to maintain tissue homoeostasis. Escaping from apoptosis or autophagy is one of the features of malignancy. PC is seriously resistant to autophagy and apoptosis, which explains its invasiveness and resistance to conventional treatment. Recently, several biological activities and pharmacological functions found in natural product extracts have been reported to inhibit PC progression. The current review focuses on understanding natural product extracts and their derivatives as one kind of novel treatments through affecting the apoptosis or autophagy in PC.
胰腺癌（PC）是最致命的胃肠道恶性肿瘤。PC 患者预后不良主要是由于缺乏针对其进行性和转移性行为的有效治疗方法。因此，找出 PC 发展的机制并进行有效的靶向治疗对于改善 PC 患者的预后具有重要意义。凋亡和自噬有助于维持组织内稳态。逃避凋亡或自噬是恶性肿瘤的特征之一。PC 严重抵抗自噬和凋亡，这解释了其侵袭性和对常规治疗的耐药性。最近，已经报道了天然产物提取物中的几种生物活性和药理功能可抑制 PC 的进展。本综述重点介绍了通过影响 PC 中的凋亡或自噬来理解天然产物提取物及其衍生物作为一种新型治疗方法。
