Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
Faculty of Chemistry, Shahid Beheshti University, G.C., P.O. Box 19396-4716, Tehran, Iran.
Chemosphere. 2021 Oct;281:130717. doi: 10.1016/j.chemosphere.2021.130717. Epub 2021 May 12.
Porous Metal-Organic Frameworks (MOFs) have emerged as eye-catching materials in recent years. They are widely used in numerous fields of chemistry thanks to their desirable properties. MOFs have a key role in the development of bioimaging platforms that are hopefully expected to effectually pave the way for accurate and selective detection and diagnosis of abnormalities. Recently, many types of MOFs have been employed for detection of RNA, DNA, enzyme activity and small-biomolecules, as well as for magnetic resonance imaging (MRI) and computed tomography (CT), which are valuable methods for clinical analysis. The optimal performance of the MOF in the bio-imaging field depends on the core structure, synthesis method and modifications processes. In this review, we have attempted to present crucial parameters for designing and achieving an efficient MOF as bioimaging platforms, and provide a roadmap for researchers in this field. Moreover, the influence of modifications/fractionalizations on MOFs performance has been thoroughly discussed and challenging problems have been extensively addressed. Consideration is mainly focused on the principal concepts and applications that have been achieved to modify and synthesize advanced MOFs for future applications.
近年来，多孔金属-有机骨架（MOFs）作为一种引人注目的材料而崭露头角。由于其理想的特性，它们被广泛应用于化学的众多领域。MOFs 在生物成像平台的发展中起着关键作用，有望为准确和选择性地检测和诊断异常铺平道路。最近，许多类型的 MOFs 已被用于检测 RNA、DNA、酶活性和小分子，以及磁共振成像（MRI）和计算机断层扫描（CT），这些都是临床分析的有价值的方法。MOF 在生物成像领域的最佳性能取决于核心结构、合成方法和修饰过程。在这篇综述中，我们试图提出设计和实现高效 MOF 作为生物成像平台的关键参数，并为该领域的研究人员提供一个路线图。此外，还深入讨论了修饰/分割对 MOFs 性能的影响，并广泛解决了具有挑战性的问题。主要关注的是已经实现的用于修饰和合成先进 MOFs 的基本概念和应用，以用于未来的应用。
