Department of Neurology, UP University of Medical Sciences, Saifai, Etawah, UP, India.
Department of Community Medicine, UP University of Medical Sciences, Saifai, Etawah, UP, India.
J Infect Public Health. 2021 Jun;14(6):734-739. doi: 10.1016/j.jiph.2021.03.005. Epub 2021 Mar 23.
Coronavirus is known to cause various systemic infections both in human and animal which are mostly mild in nature. However, recent years have seen major pandemics caused by coronavirus which are very invasive and virulent in nature. The recent SARS-CoV2 is a new addition to this list of coronavirus pandemics. So the present study was done to systematically review the CNS involvement and its manifestations in SARS-CoV2 positive patients. Systemic review of article published between 1st Dec 2019 to 31st July 2020 searched through web-based database of MEDLINE (Pubmed) and Google scholar using following keywords "COVID -19" OR "CORONAVIRUS" OR "SARS-CoV2" AND "NEUROLOGICAL" OR "CNS" OR "BRAIN". Using the steps of systemic review eight article were selected for qualitative analysis. Majority of these article were reporting neurological symptoms among patients admitted in different wards along with others general symptoms. None of the study was specifically devoted to study the neurological manifestations and complications in SARS-CoV2 positive patients. The present study concludes that there is a scarcity of good quality research which attempts to establish the role of SARS-CoV2 infection in CNS and its manifestations. However, there are evidences that CNS involvement is present in majority of the patients. Proper documentation of theses involvement and indentification of these into mild, moderate and severe infection will help in early identification and treatment of these patients.
冠状病毒已知会导致人类和动物的各种全身感染，这些感染在性质上大多是轻微的。然而，近年来由冠状病毒引起的重大大流行具有很强的侵袭性和毒性。最近的 SARS-CoV2 是冠状病毒大流行中的一个新成员。因此，本研究旨在系统地回顾 SARS-CoV2 阳性患者中枢神经系统受累及其表现。对 2019 年 12 月 1 日至 2020 年 7 月 31 日期间发表的文章进行了系统综述，通过基于网络的 MEDLINE（PubMed）和 Google Scholar 数据库，使用以下关键字进行搜索："COVID-19" 或 "冠状病毒" 或 "SARS-CoV2" 和 "神经" 或 "中枢神经系统" 或 "大脑"。通过系统综述的步骤，选择了 8 篇文章进行定性分析。这些文章大多报告了在不同病房住院的患者的神经系统症状以及其他一般症状。没有一项研究专门研究 SARS-CoV2 阳性患者的神经系统表现和并发症。本研究得出的结论是，缺乏质量好的研究来试图确定 SARS-CoV2 感染在中枢神经系统及其表现中的作用。然而，有证据表明，中枢神经系统受累在大多数患者中存在。对这些感染进行适当的记录，并将其识别为轻度、中度和重度感染，将有助于早期识别和治疗这些患者。
