Wuu J A, Wen L Y, Chuang T Y, Chang G G
Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Clin Chem. 1988 Aug;34(8):1610-3.
With an amino acid analyzer, we measured amino acids and related compounds in serum and aqueous humor from normal Chinese and some patients with extreme myopia or senile cataracts. Forty peaks were well resolved, and their areas were used to quantify each compound. In the myopic patients, glutamate, alpha-aminoadipate, and methionine concentrations in serum were 10-fold those in the normal subjects. Values for most of the other amino acids and related compounds were also higher in myopic patients' sera. In the cataract patients, concentrations of most of these compounds were lower in serum but higher in aqueous humor than for the normal subjects. Tryptophan was present in significant amounts in sera from the normal subjects, but was not detectable in the senile-cataract patients. The ratio of amino acid concentration in aqueous humor to that in the serum (Ch/Cs) was higher in the cataract patients than in normal subjects for almost all of the compounds we measured.
我们使用氨基酸分析仪测量了正常中国人以及一些高度近视或老年性白内障患者血清和房水中的氨基酸及相关化合物。四十个峰得到了很好的分离，其峰面积用于定量每种化合物。在近视患者中，血清中的谷氨酸、α-氨基己二酸和蛋氨酸浓度是正常受试者的10倍。近视患者血清中大多数其他氨基酸及相关化合物的值也更高。在白内障患者中，这些化合物中的大多数在血清中的浓度低于正常受试者，但在房水中的浓度高于正常受试者。正常受试者血清中存在大量色氨酸，但在老年性白内障患者中未检测到。对于我们测量的几乎所有化合物，白内障患者房水与血清中氨基酸浓度的比值（Ch/Cs）高于正常受试者
