Lal S, Nair N P, Isaac I, Guyda H, Quirion R
Douglas Hospital Research Centre, Verdun, P.Q., Canada.
Clin Invest Med. 1988 Jun;11(3):218-23.
The effect of hydrocortisone (HC) (200 mg, i.v. over 15 min) on the growth hormone (GH) response to the dopamine (DA) receptor agonist, apomorphine HCl (Apo) (0.5 mg sc), and on basal prolactin (PRL) secretion was studied in 11 normal male volunteers. In addition, the effect of HC on 3H-spiperone binding to rat striatal membranes was investigated. HC alone increased basal GH secretion compared with placebo (p less than 0.02) commencing 90 min after injection (p less than 0.05). When HC was given before Apo the GH response to Apo was blunted (p less than 0.05), and the delayed HC-induced increase was absent (p less than 0.001). HC or Apo alone had no effect on PRL secretion but HC plus Apo significantly decreased PRL concentrations compared with placebo (p less than 0.01) or HC alone (p less than 0.001). HC (0.1-100 microM) had no effect on 3H-spiperone binding in vitro. The mechanisms involved in the effect of HC on GH and PRL are unclear. The ability of HC to both stimulate and antagonize GH secretion points to multiple sites of action within the hypothalamic-pituitary axis.
在11名正常男性志愿者中，研究了静脉注射氢化可的松（HC）（200毫克，15分钟内注射完毕）对生长激素（GH）对多巴胺（DA）受体激动剂盐酸阿扑吗啡（Apo）（0.5毫克，皮下注射）反应的影响，以及对基础催乳素（PRL）分泌的影响。此外，还研究了HC对3H-螺哌隆与大鼠纹状体膜结合的影响。与安慰剂相比，单独使用HC可使基础GH分泌增加（p<0.02），在注射后90分钟开始增加（p<0.05）。当在Apo之前给予HC时，GH对Apo的反应减弱（p<0.05），且未出现HC诱导的延迟增加（p<0.001）。单独使用HC或Apo对PRL分泌无影响，但与安慰剂（p<0.01）或单独使用HC（p<0.001）相比，HC加Apo可显著降低PRL浓度。HC（0.1 - 100微摩尔）在体外对3H-螺哌隆结合无影响。HC对GH和PRL作用的机制尚不清楚。HC既能刺激又能拮抗GH分泌的能力表明下丘脑 - 垂体轴内存在多个作用位点。
