Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, 77843, USA.
Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, 77843, USA; Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, 77843, USA.
Curr Opin Plant Biol. 2021 Oct;63:102051. doi: 10.1016/j.pbi.2021.102051. Epub 2021 May 19.
Sensing microbe-associated molecular patterns (MAMPs) by cell surface-resident pattern recognition receptors (PRRs) constitutes a core process in launching a successful immune response. Over the last decade, remarkable progress has been made in delineating the mechanisms of PRR-mediated plant immunity. As the frontline of defense, the homeostasis, activities, and subcellular dynamics of PRR and associated regulators are subjected to tight regulations. The layered protein post-translational modifications, particularly the intertwined phosphorylation and ubiquitylation of PRR complexes, play a central role in regulating PRR signaling outputs and plant immune responses. This review provides an update about the PRR complex regulation by various post-translational modifications and discusses how protein phosphorylation and ubiquitylation act in concert to ensure a rapid, proper, and robust immune response.
通过细胞表面驻留的模式识别受体 (PRR) 感知微生物相关分子模式 (MAMP) 是启动成功免疫反应的核心过程。在过去的十年中，在阐明 PRR 介导的植物免疫机制方面取得了显著进展。作为防御的前沿，PRR 和相关调节剂的稳态、活性和亚细胞动力学受到严格调控。层状蛋白翻译后修饰，特别是 PRR 复合物的磷酸化和泛素化的交织，在调节 PRR 信号输出和植物免疫反应中起着核心作用。本文综述了各种翻译后修饰对 PRR 复合物的调控，并讨论了蛋白磷酸化和泛素化如何协同作用以确保快速、适当和强大的免疫反应。
