Meriggi E, Trossarelli G F, Carta Q, Menato G, Porta M A, Bordon R, Gagliardi L
Istituto di Ginecologia e Ostetricia dell'Università di Torino, Italy.
Diabetes Res Clin Pract. 1988 May 19;5(1):55-61. doi: 10.1016/s0168-8227(88)80079-2.
Paired capillary-venous blood samples were obtained from 418 pregnant women undergoing an oral glucose challenge test (GCT) for the screening of gestational diabetes (GD). The relationship between capillary and plasma glucose concentrations was investigated in order to establish a capillary GCT threshold. Plasma glucose was assayed by the glucose oxidase method and capillary glucose using Reflocheck Glucose strips and a Reflocheck reflectance meter. During GCT the capillary values exceeded plasma glucose values by a mean difference of 10-12 mg/dl fasting and 22-24 mg/dl after 1 h. A high correlation between the glucose values of the two techniques was found, particularly for those at 1 h, with corresponding capillary determinations being 20 mg/dl above plasma values. The sensitivity, specificity and predictive value of the various capillary thresholds investigated in detecting GD corresponded substantially to the accuracy of plasma thresholds 20 mg/dl lower. The receiver operator characteristic curves of the plasma and capillary thresholds were similar in shape and the optimal cut-off point for performing a diagnostic test was set at 135 and 155 mg/dl, respectively. These cut-off values should be reconsidered in the light of the costs and perinatal outcome.
从418名接受口服葡萄糖耐量试验（GCT）以筛查妊娠期糖尿病（GD）的孕妇中采集配对的毛细血管血和静脉血样本。研究毛细血管血糖浓度与血浆葡萄糖浓度之间的关系，以确定毛细血管GCT阈值。血浆葡萄糖采用葡萄糖氧化酶法测定，毛细血管血糖使用Reflocheck血糖仪试纸和Reflocheck反射仪测定。在GCT期间，空腹时毛细血管血糖值超过血浆葡萄糖值，平均差值为10 - 12mg/dl，1小时后为22 - 24mg/dl。发现两种技术的血糖值之间具有高度相关性，特别是在1小时时，相应的毛细血管测定值比血浆值高20mg/dl。在检测GD时，所研究的各种毛细血管阈值的敏感性、特异性和预测价值与低20mg/dl的血浆阈值的准确性基本相当。血浆和毛细血管阈值的受试者工作特征曲线形状相似，进行诊断试验的最佳截断点分别设定为135mg/dl和155mg/dl。应根据成本和围产期结局重新考虑这些截断值。
