Zhao D B, Côté S, Jähnig F, Haller J, Jäckle H
Max-Planck-Institut für Entwicklungsbiologie, Abteilung Biochemie, Tübingen, FRG.
EMBO J. 1988 Apr;7(4):1115-9. doi: 10.1002/j.1460-2075.1988.tb02920.x.
During the development of the central nervous system, Drosophila embryo axons become organized in a stereo-typed fasciculation pattern. We have found that the zipper (zip) gene, initially identified on the basis of a defective larval cuticle in zip mutant embryos, is possibly involved in the establishment or maintenance of the axon pattern during the late stages of neurogenesis. The zip wild-type gene is expressed in the developing nervous system. It codes for a putative integral membrane protein. Both the molecular features of zipper and its biological effect in the nervous system of mutants suggest that zipper is an essential component for cell surface interactions involved in axon patterning, and that the cuticle phenotype of zip mutants is dependent on the primary defects observed in the nervous system.
在中枢神经系统发育过程中，果蝇胚胎轴突会形成一种定型的成束模式。我们发现，最初根据zip突变胚胎中幼虫表皮缺陷而鉴定出的拉链（zip）基因，可能在神经发生后期轴突模式的建立或维持中发挥作用。zip野生型基因在发育中的神经系统中表达。它编码一种推定的整合膜蛋白。拉链的分子特征及其在突变体神经系统中的生物学效应均表明，拉链是轴突模式形成中细胞表面相互作用的重要组成部分，且zip突变体的表皮表型取决于在神经系统中观察到的主要缺陷。
