Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland Freiburgstrasse 18, 3010 Bern, Switzerland.
Respiratory Department, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, NSW, 2050, Australia.
Clin Chest Med. 2021 Jun;42(2):229-239. doi: 10.1016/j.ccm.2021.03.001.
Interstitial lung diseases (ILDs) are heterogenous and complex chronic lung diseases that even today are challenging to diagnose and classify. The terminology and mechanistic understanding of specific ILDs have evolved substantially over the last centuries and decades, and clinicians, pathologists, radiologists, and researchers are continuously working to untangle the various ILDs of differing causes. Despite many drawbacks and negative clinical trials, the unremitting work of ILD researchers have resulted in great therapeutic successes over the last decade. In this chapter, the authors present historical aspects of ILD and build a foundation to understand current and emerging concepts in ILD.
间质性肺疾病（ILDs）是异质性和复杂的慢性肺部疾病，即使在今天，其诊断和分类仍然具有挑战性。几个世纪和几十年以来，ILD 的术语和发病机制的理解有了很大的发展，临床医生、病理学家、放射科医生和研究人员都在不断努力理清各种不同病因的ILD。尽管存在许多缺陷和负面临床试验，但ILD 研究人员的不懈努力在过去十年中取得了巨大的治疗成功。在本章中，作者介绍了ILD 的历史方面，并为理解ILD 的当前和新兴概念奠定了基础。
